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Senior Engineer Manager Projects - Upstream

Amgen
Holly Springs, United Statesfull_timeVerifiedPosted 17 Feb 2026
💰 $158,914/yr

About the role

Career Category

Engineering

Job Description

Join Amgen’s Mission of Serving Patients 

 

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. 

 

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. 

 

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. 

 

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027. 

Senior Engineer Manager Projects - Upstream 

 

Live 

What you will do 

Let’s do this. Let’s change the world. In this vital role you will be responsible for the department capital portfolio and project management of small capital projects at the drug substance facility in ANC.    

  • Reporting to the Director of Engineering, the Sr Manager will provide technical leadership to a team of manufacturing support engineers supporting commercial production operations with emphasis on Drug Substance bioprocessing equipment.   

  • Establish clear expectations and priorities to staff. Encourage a culture of continuous improvement, partnership, and knowledge sharing. Provide development opportunities, feedback, and actively listen to staff.   

  • Cultivate a culture of safety ensuring the well-being of all staff members and drive efforts to reduce safety risks.   

  • Provide technical support to troubleshoot, identify and resolve process and system issues as needed.   

  • Be knowledgeable about compliance and regulatory aspects for equipment validation, operation and maintenance.   

  • Effectively collaborate with key customers and support groups (e.g. Manufacturing, Quality, Process Development, Maintenance, network partners).   

  • Ensure all tasks and projects are accomplished in a safe manner.   

  • Employ Business Analytics to assess performance and identify improvement opportunities 

  • Lead Sustainabilit

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Company

Amgen

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