Clinical Practice Liaison- Los Angeles, CA

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Clinical Practice Liaison

The Clinical Practice Liaison (CPL) plays a vital field-based role within Madrigal’s Medical Affairs team, focused on improving the standard of care for patients with Metabolic Dysfunction-Associated Steatohepatitis (MASH/NASH/MASLD). The CPL will proactively engage healthcare professionals (HCPs) to provide guideline-based, non-promotional disease education on the identification, diagnosis, and management of MASH.

This role centers on empowering clinical practices to adopt evidence-based care pathways, integrate non-invasive diagnostic tools, enhance risk stratification, and collaborate in multidisciplinary care models. The CPL will also serve as a bridge between the medical community and internal Madrigal teams, providing strategic insights that help shape broader corporate understanding and direction.

Key Responsibilities

Scientific & Clinical Education

• Deliver unbiased, evidence-based education on MASH/NASH to HCPs based on identified gaps in knowledge or clinical implementation.

• Present current clinical practice guidelines and real-world data on diagnosis, risk stratification, and patient management.

• Maintain deep understanding of non-invasive testing (NITs), treatment paradigms, and clinical protocols across the liver/metabolic spectrum.

Practice Engagement & Enablement

• Engage with clinicians, practice managers, and office staff to support implementation of MASH care protocols.

• Support the integration of guideline-based approaches into routine clinical workflows and align practices with payer and quality standards.

• Respond to unsolicited clinical and drug-related inquiries in a scientifically accurate and compliant manner.

Cross-Functional Collaboration

• Partner with internal Medical Affairs and Commercial colleagues to address clinical questions and ensure consistent field insights.

• Contribute scientific expertise to speaker training programs, advisory boards, and internal stakeholder education.

• Represent Madrigal at national and regional scientific meetings, supporting booth activities and engaging in peer-to-peer exchange.

Insight Gathering & Strategic Feedback

• Capture and report actionable insights from clinical practices to inform corporate strategies and educational content development.

• Monitor evolving clinical trends and barriers to care in MASH/NASH to support internal planning and market awareness.

Compliance & Professional Standards

• Adhere strictly to all applicable company and regulatory policies, including FDA and industry guidelines for non-promotional medical engagements.

• Ensure thorough documentation and accountability for all scientific interactions.

Qualifications & Skills

Required:

• Advanced healthcare or life science degree (e.g., PA, NP, PharmD, or other clinically relevant background).

• Minimum 5 years of direct patient care in gastroenterology, hepatology, endocrinology, or metabolic disease.

• Clinical familiarity with NASH/MASH diagnostic tools, especially non-invasive testing and risk stratification methods.

• Strong grasp of U.S. healthcare system operations, including practice workflows, billing/coding, and payer dynamics.

• Excellent verbal and written communication skills; ability to distill complex science for various audiences.

• Proficiency with Microsoft Office tools, CRM platforms, and virtual communication systems.

• Willingness to travel 60–70% weekly, including weekends for scientific congresses.

Preferred:

• Previous experience in the pharmaceutical or biotech industry in a medical affairs or MSL role.

• Understanding of industry standards for compliant medical information exchange and field-based scientific roles.

Ideal Candidate Profile

The ideal CPL candidate is a dynamic communicator and clinician-educato