Senior Scientist II Cellular and Spatial Biology

Job title: Senior Scientist Cellular and Spatial Biology

• Location: Cambridge, MA

About the Job

We are looking for a highly motivated and innovative scientist to join the Target, Disease & Systems Biology (TDSB) department at Sanofi as a Senior Scientist. In this role, you will collaborate across the Pre-clinical Omics research cluster to investigate disease biology, uncover novel pathways and mechanisms, and identify strategies to address unmet medical needs across a range of therapeutic areas.

This position offers the opportunity to apply cutting-edge molecular biology and spatial technologies to advance our therapeutic discovery efforts. The ideal candidate will bring strong technical expertise in bulk RNA-seq, single-cell/single-nucleus RNA-seq (sc/snRNA-seq), spatial transcriptomics, and spatial proteomics to support a broad scope of research initiatives.

We are seeking someone who can lead and execute scientific research, analyze and present complex data, and communicate effectively with both expert and non-expert audiences. Strong organizational skills—including meticulous record keeping, planning and scheduling, and maintaining laboratory equipment—are essential. The successful candidate will be curious, bold, and creative in exploring new scientific directions and proposing innovative experimental approaches.

At Sanofi, we are an innovative global healthcare company driven by a singular purpose: to chase the miracles of science to improve people’s lives. We offer a dynamic environment where you can thrive professionally, build meaningful connections, and push the boundaries of scientific discovery. Ready to begin your journey?

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main responsibilities:

• Experimental Design & Execution:

• Design and perform experiments using bulk RNA-seq, single-cell/single-nucleus RNA-seq (sc/snRNA-seq), NGS and spatial assays (GeoMx, Visium, Xenium, Phenocycler-Fusion) on human and non-human biological samples.

• Optimize and troubleshoot protocols for molecular and spatial assays.

• Data Analysis & Interpretation:

• Collaborate with bioinformatics teams to analyze high-dimensional omics data.

• Interpret results to guide therapeutic target identification and validation.

• Technology Development & Innovation:

• Evaluate and implement emerging molecular biology and spatial technologies.

• Contribute to the development of novel workflows and platforms.

• Cross-functional Collaboration:

• Work closely with scientists across biology, chemistry, and computational disciplines.

• Present findings in internal meetings and contribute to strategic research discussions.

• Work with Program teams to represent TDSB and to suggest TDSB capabilities to help push program support.

• Documentation & Reporting:

• Maintain detailed experimental records.

• Prepare technical reports and presentations.

About You

• Master’s degree in Molecular Biology, Cellular Biology, Genomics, Neurobiology or a related field with 5+ years of relevant post-master’s experience or Ph.D. in Molecular Biology, Cellular Biology, Genomics, Neurobiology or a related field with 3+ years of post-doctoral experience (academic or industry)

• Demonstrated expertise in transcriptomics and spatial biology.

• scRNA-seq and snRNA-seq

• Bulk RNA-seq

• Next-Gen Sequencing (NGS)

Preferred qualifications:

• Spatial transcriptomics platforms (e.g., 10x Genomics Visium and/or Xenium, NanoString GeoMx).

• Spatial proteomics technologies (e.g., Akoya CODEX/Phenocycler-Fusion)

• Proficiency in tissue handling, imaging, and histological techniques.

• Familiarity with bioinformatics tools and pipelines for omics data analysis.

• Strong problem-solving skills and ability to work independently and collaboratively.

• Excellent communication and organizational skills.

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future-focused team.