Senior Scientist - Discovery Chemistry - Targeted Protein Degradation

Job Description

Our research laboratories in Rahway, New Jersey are focused on the discovery and development of world-changing therapeutics. Co-located with the corporate headquarters, our multi-disciplinary research site offers cutting edge technology and resources to explore the most promising science combined with our company’s world-class R&D expertise for inventing medicines. Located in the greater New York City metropolitan area, research conducted in our state-of-the-art facility drives all aspects of drug discovery, development, manufacture, and commercialization of small molecules, biologics, and vaccines.  

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough to impact the lives of patients, which relies on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our research laboratories, you will have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

Job Description:

Our Company is currently seeking exceptional chemists to join our highly collaborative Targeted Protein Degradation (TPD) team within Discovery Chemistry Department located in Rahway, New Jersey. The successful candidate will contribute to multidisciplinary discovery teams by applying innovative chemistry, analytical techniques, and data analysis to the design and synthesis of drug candidates. They will also contribute to the development and application of drug discovery chemistry platforms in the field of TPD. There is ample opportunity for knowledge expansion and career growth through collaborations with talented and dedicated colleagues across functional areas and sites.

Key Responsibilities:

• Act as a leader in the laboratory, executing chemistry to deliver on program strategy

• Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills to build structure-activity relationships

• Design, synthesize, and characterize molecular glues or heterobifunctional degraders to enable target identification and validation, hit-to-lead, and lead optimization programs

• Provide scientific mentoring and technical training of team members

• Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal and communication skills with scientists at all levels.

• Effectively and proactively communicate key results and enable data driven decision making.

• Share in responsibilities to support general lab function and promote a culture of safety

• Contribute to writing and conceptual framework of publications, presentations, and patents when appropriate; thereby, establishing a significant external scientific presence

• Establish and maintain a detailed knowledge of relevant literature

• Work in a matrix environment to solve problems.

We are looking for professionals with the following skills to achieve our goals:

Minimum Requirements:

• Bachelor’s degree in chemistry, Chemical Biology, Medicinal Chemistry, or related scientific discipline with seven (7) years' experience.

• Or master’s degree in related fields with four (4) years' experience

• Or PhD in related fields (received by January 2025) with 0 -2 years’ experience is highly preferred

Other Basic Qualifications:

• Excellent interpersonal and communication skills are paramount

• Experience with scientific problem solving and troubleshooting technical issues

• Demonstration of collaboration and a proven record of solving complex problems in a team environment

• Candidate will have a passion for pushing the boundaries of scientific knowledge and a learning mindset about adaptation of new methods

• Must have a sense of urgency and drive to work in our cutting-edge research lab

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience in targeted protein degradation

• Experience with molecular glues

• Experience with cutting-edge high throughput chemistry and experimentation techniques

NOTICE FOR INTERNAL APPLICANTS

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