VAC_20_2025 - RESEARCH ASSISTANT (3D Chromatin Organization group)

The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive cancer research center dedicated to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010, and since then has experienced an exponential growth.

The IJC is also part of the network of Excellence Research Centers of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC) Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as Accredited Health Research Institute (IIS) by the Carlos III Health Institute (ISCIII).

The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has six locations integrated into reference hospitals: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Josep Trueta, Hospital del Mar and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice in clinical settings.

The Josep Carreras Leukemia Research Institute Can Ruti is looking for a Research Assistant in training for the 3D Chromatin Organization group led by Dr. Biola M. Javierre. This contract is part of the project PID2021-125277OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, EU.

MAIN RESPONSABILITIES

The Javierre Team is a group of passionate scientists with an insatiable thirst for learning about spatio-temporal organization of the DNA. Our group combines cutting-edge experimental and bioinformatics approaches to understand the specific 3D chromatin organization of cell differentiation and malignant transformation. Our long-term goal is to keep taking steps forwards in the fight against cancer. We will be unstoppable until we cure it.

Our research group investigates the generation of B cell lymphocytes and how alterations in this process lead to B cell malignancies, such as B cell acute lymphoblastic leukemia or diffuse large B cell lymphoma. To achieve this, we utilize mouse models and human primary samples, applying cellular and molecular methods, omics, and computational biology. Our ultimate goal is to identify new therapeutic targets and biomarkers for cancer patients to improve their quality of life.

The main research goals of our lab are:

• Defining the cell type-specific 3D chromatin organization along cell differentiation.
• Identifying the altered DNA topology in cancer

• Study non-coding mutations to prioritize new candidate genes and pathways related to cancer

For more information, please contract 3D Chromatin Organization Research Group's webpage (https://www.javierrelab.com/) and the IJC web page (https://www.carrerasresearch.org/en/3d-chromatin-organization_78766).

MAIN RESPONSIBILITIES

• Mouse genotyping
• Molecular Biology techniques for RNA and DNA analysis
• Flow Cytometry assays

WHAT WE NEED

General skills

• A person with a FP degree or superior in research assistance.
• Ability to handle varying workloads and aptitude for teamwork.
• High level of collaborative and communicative skills.
• Good level of English speaking and writing skills (required). Spanish (helpful).

Technical skills

• FP degree in research assistance related with biomedicine, molecular biology, immunology or similar.

WHAT WE OFFER

• An exciting and innovative research project.
• Be part of a young, collaborative and international work environment with cutting-edge technologies and interdisciplinary teams of scientists, including experts in medicine, immunology, genomics and bioinformatics.
• An exciting and innovative research project.
• The stimulating environment of the Barcelona metropolitan area.
• Training contract
• Career Development