Senior Scientist II Toxicology, Non-Clinical Development & Clinical Pharmacology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

In anticipation of the Company’s growth plans, we are seeking an experienced Toxicologist to lead safety strategies for small molecule discovery programs and work in close collaboration with colleagues in Research and Development to enable the advancement of portfolio programs. The ideal candidate will deliver a balanced assessment of the risk/ benefit profile associated with a drug candidate by integrating pharmacology/ toxicology studies and engaging with stakeholders to align on a tractable clinical development plan. Further, the ideal candidate will:

• Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for patient safety.

• Design and oversee nonclinical toxicology programs and strategies to advance pipeline of small molecule cancer therapeutics from research phase through clinical development and life-cycle management.

• Effectively implement and oversee studies outsourced to CROs, in collaboration with study operations, pharmacology, DMPK and clinical pharmacology functions.

• Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings and recommendations to internal project teams and leadership.

• Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making.

• Author and review regulatory documents (pre-IND briefing books, INDs, Investigator Brochures, DSURs, etc…) and interact with regulatory agencies (FDA, MHRA, EMA, etc.).

• Develop and implement target de-risking, screening, issue mitigation, and resolution strategies for toxicities observed in vivo.

Required Experience, Skills, and Education:

• Ph.D. degree in toxicology, pharmacology, or related discipline with 5+ years of leadership experience in toxicology project development; DABT certification is desirable.

• Experience preparing nonclinical safety sections supporting IND/NDA submissions using CTD format.

• Interactions with FDA and other regulatory agencies.

• A thorough understanding of GLP regulations as well as US and ex-US regulatory guidance documents.

• Experience with small molecule drug discovery and development, including the use of screening assays for toxicity endpoints.

• Strong scientific background and scientific aptitude with excellent critical thinking skills.

• Ability to work effectively and collaboratively on cross-functional project teams; demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team.

• Excellent verbal, presentation, and written communication skills.

• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high-energy, small company environment.

Preferred Skills:

• Prior experience with oncology therapeutics is highly desirable.

The base salary range for this full-time position is $175,000 to $200,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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