Senior Scientist - Halic Lab

We are looking for an accomplished and enthusiastic researcher to join the Department of Structural Biology as a Senior Scientist to drive new, interdisciplinary research initiatives. The successful candidate will focus on cryo-electron tomography to explore chromatin processes in cells. Expertise in cryo-electron microscopy is required and some experience in cryo-ET is preferred.

The World’s Brightest Minds Always Innovate  

At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. 

The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology approaches. We apply genetics and molecular biology tools to investigate heterochromatin formation in fission yeast and we use cryo-EM to examine chromatin organization and dynamics. While we have focused mainly on single-particle analyses of reconstituted complexes, we aim to use cryo-ET to visualize chromatin processes in their native environment, i.e., inside the nuclear compartment.

More information about the lab and ongoing projects can be found here. Come join us as we embark on the next step of structural biology!

You will be part of a vibrant community at the Department of Structural Biology at St. Jude Children's Research Hospital, with state-of-the-art facilities that enable integrative structural biology and biophysics investigations — including cryo-EM, X-ray crystallography, biomolecular NMR, single-molecule imaging, protein-protein interactions — combined with computational and data-science approaches. More information about our department can be found here.

Our Cryo-EM Center features a 300keV Titan Krios and a 200keV Talos Arctica electron microscopes, each equipped with K3 direct electron detector and BioQuantum energy filter. A second Titan Krios with Falcon 4i and Selectris X imaging filter is dedicated to cryo-ET projects. The Center was recently upgraded with a Zeiss Crossbeam FIB-SEM and a ThermoScientific Arctis Cryo-Plasma-FIB will be added soon.

In addition, the Center hosts advanced equipment for sample preparation, screening and optimization: ThermoFisher Talos L120C TEM, ThermoFisher Vitrobot Mark IV System, Leica EM GP2 automatic plunge freezer, Gatan Solarus II plasma cleaner, PELCO easiGlow Glow Discharge Cleaning System, and TED PELLA carbon coater 208C. The Center is supported by state-of-the-art computational resources including a dedicated GPU cluster and DDN file storage, and has ready access to the high-performance computing facilities at the St. Jude Data Center.

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required.
• Graduate degree preferred.

Minimum Experience:

• Ten (10) years relevant post-degree work experience is required with a Bachelor's degree.
• Eight (8) years of relevant post-degree work experience is required with a Master's degree.
• Six (6) years of relevant post-degree work experience is required with a PhD.

The World’s Best Stop at Nothing  

There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Glassdoor’s “Best Places to Work” list. Actually, there are more than 5,500 reasons. At our world-class pediatric research hospital, every one of our 5,500 professionals shares our commitment to making a difference in the lives of the children we serve. There’s a unique bond when you are part of a team that will stop at nothing to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where all employees, regardless of their role, receive the resources, support, and encouragement to advance and grow their careers. 

Better at Work. Better at Life. 

When you work at St. Jude, you’ll join a highly collaborative work culture that inspires you every day to be your best.  With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and