Scientist II/Senior Scientist, Preclinical Research

We are seeking a Scientist II/Sr. Scientist to evaluate novel genome editing systems for in vivo therapeutics as a member of our growing pre-clinical research team. Reporting to an Associate Director and Project Team Lead, the role is key to understanding the activity of our gene editing systems in therapies. This position contributes to characterization of a therapeutic target as well as the effects of gene editing in both cells and animal models. The role is highly collaborative and will impact our approach to new therapies as well as advancing current programs to clinical. This role will be based in Emeryville, California.

How you’ll contribute: 

• Edit relevant primary cells and cell lines to support lead finding and selection for pipeline programs
• Perform analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing
• Analyze the effect of gene editing and develop functional readouts employing biochemical and immunofluorescence techniques
• Collaborate internally and with external partners on the optimization of non-viral delivery approaches
• Utilize non-viral and viral delivery approaches to plan in vivo studies and perform various molecular analyses to support internal therapeutic programs (handling animals not required)
• Independently trouble-shoot technical issues as needed
• Analyze and interpret experimental data and present results at team meetings and company-wide meetings
• Contribute to the selection/design of therapeutic strategies
• Provide mentorship / training to research associates as appropriate
• Prepare accurate and timely data summaries and contribute to writing of reports, papers, and patent manuscripts
• Present at internal and external scientific meetings

What you bring:

• PhD in biology , biochemistry, molecular biology, gene editing, or a related discipline
• At least 2+ years of relevant research experience after PhD or a  BS/MS degree with 10+ years of experience (molecular / cell biology required, gene therapy or gene editing experience is desirable). 
• Publication record of biological discovery and/or methods development as evidenced by primary authorships in scientific journals is highly desirable.
• Experience with cell culture and nucleic acid delivery techniques, 
• Experience with quantitative PCR and/or digital droplet PCR
• Experience with biochemical analysis techniques (Western Blot, ELISA, Enzyme activity assays, Immunostaining)
• Experience with NGS data generation and interpretation
• Effective oral and written communication skills
• Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities
• Ability to work independently as well as in a results-oriented team
• Able to quickly learn and adapt to new software tools 
• Thrives in a fast-moving, results-oriented startup environment with urgent deadlines
• Self-motivated, passionate about your work, and eager to continuously learn more

California Pay Transparency Disclosure:

This position is classified as an exempt position under the Federal Labor Standards Act.  The anticipated base salary range for this position will be $130,000 to $170,000.  You will also be eligible to receive equity, bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.

What makes Metagenomi a unique place to work?

• We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic de