Senior Principal Scientist, Chemical Biotechnologies

Job Description

Description:

The Senior Principal Scientist reports to the Senior Director Chemical Biotechnologies of Process Research & Development Enabling Technologies, our Company's Research Laboratories. As a scientific leader within Chemical Biotechnologies (CBT), they are responsible for delivering technical innovation, both personally and through mentorship of others, and in driving the scientific strategy of the CBT group. The Senior Principal Scientist manages and prioritizes a portfolio of work that includes direct project support of the current our Company's clinical pipeline and prospective technology development that enhances our ability to deliver on the pipeline of the future. This includes technical oversight of laboratory-based process development and characterization, scale-up and activities to support technology transfer and regulatory filings.

The CBT group is an interdisciplinary team responsible for the discovery, development, and application of proteins and other biomolecules to support our Company's Pipeline from Discovery to Commercial launch across small molecules, biologics, and vaccines. The Senior Principal Scientist cultivates and drives scientific excellence and innovation by contributing their expertise and experience to drive invention and implementation of new biomolecule applications. As a scientific leader with deep subject matter expertise in chemistry, biocatalysis and protein engineering, they will be expected to impact the scientific strategy and portfolio broadly, including via their own lab experimentation and their guidance of fellow scientists both in and out of the lab. They will also use their network and knowledge of emerging biotechnology advances to drive these contributions.

Critical tasks include: (1) developing innovative enzymatic solutions to complex chemistry problems across a diverse portfolio of projects from the preclinical to commercial synthesis phase, (2) advancing novel capabilities to design, generate, and test libraries of engineered proteins with world-class efficiency, (3) mentoring, coaching, and training scientists both in and out of the lab to drive technical excellence, and (4) proactively identifying and capitalizing on impactful new opportunities and applications of biomolecules across modalities. These tasks will enable the incorporation of improvements to existing workflows and invention of new ones that fundamentally shift our ability to deliver on the pipeline of the future.

A successful candidate is expected to collaborate with their peers on developing strategies and priorities for biomolecular applications. They are responsible for working closely with their counterparts across Development Sciences and Clinical Supply (DSCS), Discovery, Preclinical and Translational Medicine (DPTM), and our Company's Manufacturing Division, to deliver on their critical tasks.

Through their scientific leadership, strategic input, and mentorship, the Senior Principal Scientist will ensure that we develop and deliver innovative, robust, safe and economical processes that meet project timelines with the best science at first filing toward world class supply targets. This role is also responsible for directing the preparation and approval of disclosures to be used as the basis for patent applications, publications and external presentations. As such, a strong, established reputation for scientific excellence supported by publications and external presentations is expected.

Nature and Scope of Position:
This role reports to the Senior Director of Chemical Biotechnologies within Enabling Technologies, Process Research & Development in our Company's Research Laboratories organization. They will establish a viable succession plan for their own role, which is a key leadership position within the functional area. In addition, the Senior Principal Scientist will actively demonstrate and encourage diversity and inclusion principles in their approach to problem solving and talent development.

Aside from those already mentioned above, a critical task includes technical and strategic mentorship of CBT staff who directly contribute to the discovery, design, development, and application of proteins and other biomolecules to our Company's Pipeline of today and tomorrow. The incumbent will progress and guide the experts within the group to develop novel matter and innovative processes that enable the delivery of life-saving medicines to patients in need. They will collaborate closely with their internal partners especially in PR&D and Analytical R&D, as well as external Contract Research Organizations, Contract Manufacturing Organizations, and academic labs to execute on these responsibilities. The processes are ultimately demonstrated and validated at internal and external commercial supply sites and documented in technology transfer document