Senior Scientist I (In Vivo Pharmacology)

SUMMARY/JOB PURPOSE (Basic purpose of the job):

The Senior Scientist I is responsible for supporting in vivo pharmacology research efforts for various Biotherapeutics projects.  The strong candidate must be a highly self-motivated, interactive, and productive hands-on PhD scientist. This individual will possess strong knowledge and hands-on experience with various animal models in cancer biology and immuno-oncology and be able to strategically incorporate the latest technologies into Pharmacology functions. The candidate must have a deep understanding of the concept of PK, PD, and efficacy, and be able to interpret their relationship.

ESSENTIAL DUTIES/RESPONSIBILITIES:

• Lead, design, execute and interpret in vivo pharmacology (PK/PD/Efficacy) experiments to test the selected compounds in rodent tumor models.

• Hands-on in vivo work is required with support for external CRO studies when needed.

• Represent the Pharmacology function on Biotherapeutics project teams.

• Provide scientific support for the project teams and Biotherapeutics/Translational Pharmacology staff.

• Utilize literature and internal data sets to design and test hypotheses for drug targets.

• Prepare Pharmacology study reports for research findings and support IND filings.

• Collaborate with the IACUC committee to ensure compliance with internal policies and animal welfare regulations.

SUPERVISORY RESPONSIBILITIES:

• None.

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

• BS/BA in Pharmacology, Cancer Biology, Molecular Cellular Biology or related field and a minimum of 7 years relevant experience; or,

• MS/MA in Pharmacology, Cancer Biology, Molecular Cellular Biology or related field and a minimum of 5 years relevant experience; or,

• PhD in Pharmacology, Cancer Biology, Molecular Cellular Biology or a closely related field and 0 years of relevant experience; or,

• Equivalent combination of education and experience.

Experience:

• Deep understanding of in vivo Pharmacology (PK, PD and efficacy) concepts for oncology drug discovery including I-O biology and related drug mechanisms.

• Extensive experience using in vivo tumor models for drug discovery with a proven track record in hands-on establishment, validation, and implementation of animal models for testing cancer therapies, including xenograft, syngeneic, genetically engineered mouse, orthotopic, PDX and humanized models to study biologic mechanisms.

• Proven track record of writing regulatory and IND filing documents in the pre-clinical Pharmacology section.

• Proven track record of good experimental design, in-depth data analysis and interpretations based on strong scientific rationale.

• Expertise in cell culture with aseptic technique and basic in vivo techniques (handling different routs of administration, blood collection, etc.) is a must.

• Strong scientific expertise with a good track record of publications.

• Experience working with CROs to coordinate and execute studies in a timely manner.

Knowledge, Skills and Abilities:

• In vivo skills including, but not limited to, animal handling, dosing with different routes (po, iv, sc, ip, im, etc.), blood collection, tissue collection/perfusion, necropsy, tumor measurement, clinical observation, and rodent survival surgeries.

• Solid biological and mechanistic understanding of biologics in oncology and immune-oncology including specific and specialized readouts and protocols for in vivo studies.

• Understanding the regulations and guidelines of IACUC and AAALAC is a must.

• Has flexibility to adapt to a fast-paced work environment and coach junior scientists.

• Excellent oral and written communication and presentation skills.

• Detail-oriented and able to problem-solve and offer potential solutions.

• Strong communication skills, excellent work ethic, self-motivation and ability to work effectively either in a team environment or independently.

• Advanced knowledge of MS Office, .pdf, GraphPad, Benchling notebook, and Studylog is required.

Work Environment/Physical Demands:

• May require weekend and holiday work to support in vivo studies.

Our office is a modern space that fosters collaborations and creativity.  Teams work closely together, sharing ideas and solutions in a supportive atmosphere.  We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable wo