Senior Research Associate, In Vivo Pharmacology

What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Since Flagship’s founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.  

Flagship is an experiment in institutional, entrepreneurial innovation practiced in the context of a small company with an insurgent mindset.  We are seeking individuals with an entrepreneurial spirit to help build up Pioneering Medicines, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment.  The level of the role will be commensurate with the education and years of experience of the identified candidate.

Pioneering Medicines is a newly formed initiative dedicated to conceiving and developing an innovative pipeline of first-in-category therapeutic products that will leverage Flagship's platform companies and extend beyond the programs the companies develop on their own.

Position Summary:

We are seeking a Senior Research Associate in the In Vivo Pharmacology group who will be responsible for independently developing and performing studies with animal models across multiple disease areas, including oncology, autoimmunity and metabolism. This individual will collaborate with in vitro biology, translational science and nonclinical groups to help execute on company strategy.

Key Responsibilities:

• Support the screening, characterization, and mechanism of action studies for drug candidates of various modalities, including small molecules, biologics and nucleic acids
• Generate high quality data using in vivo models of oncology, autoimmunity and metabolism. 
• Monitor animal health, accurately record data and comply with IACUC regulations in regard to animal welfare and care.
• Help develop ex vivo assays in conjunction with translational science to determine relevant pharmacodynamic biomarkers and mechanism of action of targets/programs within PM.
• Collaborate with colleagues within the larger in vivo group, in vitro biology, and translational teams to support PM’s daily operations in both the vivarium and the main laboratory.

Basic Requirements:

• BSc or advanced degree in Biology or related disciplines with 2+ years of experience in animal handling within a research setting.
• Expertise in multiple forms of substance administration (e.g., PO, IP, IV, SC)
• Experience in necropsy, tissue collection and processing.
• Demonstrated ability to execute or learn various in vitro and ex vivo assays (e.g., cell culture, ELISA, Flow cytometry)
• Proficient in scientific software (e.g., Excel, GraphPad Prism, FlowJo)
• Ability to analyze scientific data and clearly communicate summarized data to internal PM team members and stakeholders.
• Accurately record detailed documentation of experimental results via ELN (Electronic Lab Notebook).
• Ability to operate as part of a team and work with colleagues across the organization to advance projects at all stages.

Additional Qualifications:

• Research background in oncology, immunology, or metabolism in an industry or academic setting preferred.
• Previous experience with animal models of oncology and autoimmunity preferred.
• Hands-on experience with flow cytometry is a plus.

#LI-LS1

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.   Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.