Executive Director, Health Technology

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Executive Director, Health Technology serves as the enterprise technical expert focused on accelerating the adoption and integration of Madrigal therapies within health system infrastructure, particularly Electronic Health Records (EHRs), clinical decision support tools, and digital workflows across Integrated Delivery Networks (IDNs).

This role will partner with Market Access, Medical, Marketing, Diagnostics, and Key Account Directors (KADs) to enable and operationalize pathway and protocol implementation through technology. The individual will work directly with health systems to ensure that approved protocols, diagnostics, and treatment pathways are effectively embedded into EHRs and care delivery workflows, reducing friction and accelerating time to therapy.

Key Responsibilities

1. Health Technology & EHR Strategy

• Serve as Madrigal’s subject matter expert on EHRs, clinical decision support, and health system technology infrastructure
• Develop strategies to integrate therapies, diagnostics, and care pathways into EHR systems (e.g., test order sets, alerts, documentation workflows)
• Identify opportunities to leverage technology to improve patient identification, prescribing efficiency, and time-to-therapy
• Define and advance Madrigal’s strategy for integrating AI/ML-driven capabilities within EHRs and digital health platforms to enable scalable patient identification, risk stratification, and clinical decision support
• Stay current on evolving health IT standards, interoperability, and digital health innovations impacting IDNs

2. IDN Technology Enablement

• Partner with KADs and account teams to support technology-driven pathway and protocol implementation within IDNs
• Engage directly with health system IT, informatics, and clinical operations leaders to facilitate adoption
• Translate clinical and access strategies into scalable, system-level technology solutions
• Support prioritization of accounts based on technical readiness and opportunity for impact

3. Cross-Functional Partnership

• Work closely with Marketing, Medical, Diagnostics, and Market Access to ensure alignment between strategy and technical execution in alignment with corporate and brand strategies
• Support field teams by providing technical expertise in account engagements and executive discussions
• Collaborate with Diagnostics to ensure testing workflows are integrated into EHR-driven patient identification processes

4. Workflow Optimization & Implementation

• Map and analyze end-to-end clinical and operational workflows within health systems to identify friction points
• Design and recommend technology-enabled solutions to streamline prescribing, approvals, and therapy initiation
• Champion the use of advanced analytics and AI/ML (including EHR-integrated algorithms, predictive modeling, and NLP) to drive scalable patient identification, stratification, and proactive care pathway optimization. Identify and address operational and technical barriers to adoption

5. Insights & Innovation

• Provide ongoing insights into health system technology trends, EHR capabilities, and digital adoption barriers
• Inform internal strategy by translating account-level learnings into scalable best practices
• Continuously assess emerging AI and digital health innovations (e.g., ambient AI, real-world data models, EHR-native algorithms) and translate them into actionable opportunities to accelerate diagnosis and treatment of MASH
• Partner with i