Senior Research Associate (Oligo Chemistry & Biochemistry)

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform.  Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

 

Description

Wave Life Sciences is seeking a highly motivated Research Associate or Associate Scientist in Oligo Chemistry and Biochemistry Research to join its team in Cambridge, Massachusetts. This is an ideal opportunity for an individual who is interested in learning cutting edge technologies and who thrives in a team-oriented, fast-paced, cross-disciplinary biotech environment. The candidate will take an active role in LC/MS based bioanalytical chemistry, oligonucleotide stability assay, and oligonucleotide metabolite identification for discovery and preclinical activities. 

 

Experience

• B.S. or M.S. in Chemistry, Analytical or Bioanalytical chemistry with 1-5 years of laboratory experience.
• Experience or understanding of the extraction technique of oligonucleotide (or small molecules, biopolymers) from biological matrices.
• Experience or understanding of LC/MS analysis of oligonucleotide is highly preferred.
• Experience of laboratory software such as ChemDraw and GraphPad is preferred.
• Demonstrable organizational and time management skills.
• Ability to be highly productive and innovative in a fast-paced work environment.

 

Responsibilities

• Play a key role in LC/MS based bioanalytical chemistry with synthetic oligonucleotides for multiple projects/targets.
• Perform proper oligonucleotide extraction protocols (LLE, SPE, immunoprecipitation etc) for the sample preparation.
• In vitro stability assays of synthetic oligonucleotides in biological matrices.
• Characterization and identification of oligonucleotide metabolites from in vivo experiments by analytical techniques, such as LC/MS.
• Operate and maintain lab equipment such as LC/MS, UV spectrophotometer, Nanodrop, centrifuge, etc.
• Maintain detailed written and electronic records of experimental protocols and data in accordance with company policy.
• Presentation of results in written and oral format within a multidisciplinary team.
• Establish and maintain excellent working relationships within the team and collaborative partners throughout the company.
• This position will be in person at our Cambridge MA location, five days a week.

 

Pay Range External Disclosure Statement

 

The annual base salary range for this position is $72,000 - $98,000.

 

The range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity.  This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives.  In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being. These include, but are not limited to, company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program.

 

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, nati