Principal Research Scientist II

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Small Molecular Therapeutics and Platform Technologies (SMTPT) within Discovery Research seeks an accomplished scientist with hands on chemistry experience across multiple modalities (small molecules, degraders, macrocycles, peptides) to lead and build a new team of scientists within the Global Medicinal Chemistry (GMEC) organization.  GMEC is committed to delivering first and best-in-class small molecules in both conventional and unconventional drug-like space across modalities with the potential to improve human health.  The Principal Research Scientist II will lead a team of chemists designing and synthesizing macrocyclic peptides aimed at identifying and advancing low dose leads across our portfolio and in collaboration with teams across Lake County, IL, Boston, San Francisco, Ludwigshafen, and Madison.

The candidate will be responsible for managing a diverse team of 6-8 scientists who contribute to the design and synthesis of drug candidates for novel targets throughout AbbVie’s drug discovery pipeline and are tasked with enhancing AbbVie’s peptide platform capabilities in Lake County.  The team will develop novel chemistry strategies and execute multiparametric optimization(s) of drug candidate properties in a highly collaborative environment aimed at accelerating the delivery of a sustainable pipeline of first in class/breakthrough permeable peptides.

The candidate will have experience with project conception, strategic planning, and chemistry as well as contributing to cross-functional and matrixed teams.  The candidate will have strong theoretical and practical expertise in modern medicinal chemistry, peptide design and synthesis, macrocyclic design and synthesis, and Bro5 optimization including an appreciation