Senior Manager, People Operations

Role Overview & Key Functions:

SUMMARY:

The Senior Manager, People Operations is responsible for leading and optimizing core employee lifecycle processes across the organization. This role serves as a trusted partner to leaders and employees, ensuring operational excellence, compliance, and a seamless employee experience throughout all stages of employment. The Senior Manager will oversee HR operational programs, lead process improvement initiatives, and partner cross-functionally to support the company’s people strategy

At Karyopharm, our HR team is a strategic partner to the business while creating a thoughtful, high-quality employee experience grounded in collaboration, responsiveness, and continuous improvement.

 

RESPONSIBILITIES:

• Leads and oversees the employee onboarding and offboarding experience in partnership with key stakeholders.
• Partners with HR leadership to develop and execute strategic People Operations initiatives aligned with business objectives.
• Oversees employee recognition and engagement programs to support a positive and inclusive company culture.
• Manages and enhances onboarding programs, including onboarding agendas and the new hire buddy program.
• Ensures compliance with employment eligibility verification requirements and oversees all I-9 documentation processes.
• Provides guidance to employees and managers regarding HR policies, procedures, and best practices.
• Collaborates cross-functionally with IT, Payroll, Facilities, Administration, Quality, Legal, and other teams to ensure operational effectiveness.
• Oversees HRIS data integrity, reporting, employee records management, onboarding and offboarding documentation, and audit readiness.
• Drives process improvement initiatives and implements scalable operational efficiencies across HR workflows and procedures.
• Manages vendor relationships related to background checks, immigration, employment verifications, HR systems, and other HR operational services.
• Partners with HR Centers of Excellence during key annual processes, including performance reviews, compensation planning, succession planning, and engagement surveys.
• Oversees legal contract coordination, budget tracking, and purchase order processing for the HR function.
• Assists and manages immigration processes for new and existing employee cases in partnership with external counsel and internal stakeholders.
• Partners with Compensation and Finance teams to support equity administration and organizational planning processes.
• Collaborates with HR leadership to execute strategic Human Resources initiatives and change management activities.
• Leads the review and maintenance process to ensure all job descriptions are accurate, compliant, and aligned with organizational structure.
• Facilitates new hire orientation sessions and supports leadership development and employee training initiatives.
• Oversees offboarding activities, including separation documentation, benefits communications, exit interviews, and risk mitigation activities.
• Partners with Payroll to ensure accurate and timely payroll-related documentation and processing.
• Supports Inclusion & Wellness initiatives and programs through strategic planning, communication, and execution.
• Leads HR compliance activities related to GxP training records, audit readiness, SOP management, and documentation retention requirements.
• Partners with Talent Acquisition and hiring managers to support workforce planning, hiring operations, and onboarding activities.
• Leverages AI-driven tools, HR analytics, and workforce data insights to enhance operational efficiency, support strategic decision-making, improve employee experience, and drive continuous process improvement across the HR function. Develops and analyzes HR metrics and reporting related to turnover, headcount, engagement, and operational performance.
• Leads the adoption and governance of AI-enabled HR technologies and people analytics to optimize workforce planning, operational effectiveness, and employee engagement strategies.
• Acts as a trusted advisor to managers and employees on employee relations matters, organizational changes, and HR operational practices.
• Ensures compliance with federal, state, and local employment laws, including leave administration, accommodations, and policy administration.

Candidate Profile & Requirements:

 

REQUIREMENTS:

• Bachelor’s degree; Master’s degree or HR certification preferred.
• Minimum of 8 years of Human Resources experience, including at least 5 years in HR Operations or People Operations leadership roles.
• Experience leveraging AI tools and technologies to improve