Pioneering Medicines Director, In Vitro Pharmacology

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 11 programs ongoing with plans to have more than 15 programs in 2024. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking a highly motivated and strategic In Vitro Pharmacology leader to support a growing portfolio of assets. This key leadership role will require an individual to direct and oversee in vitro pharmacology efforts, participating in drug discovery and early development activities. The role will involve functional accountability to support assets across a diverse range of modalities and therapeutic areas, including oncology, inflammation, and metabolic diseases. The candidate will work in cross-functional teams leading and supporting the activities, delivering research leadership, and managing/mentoring junior scientists. The successful candidate is expected to proactively build and maintain strong collaborations with Flagship Pioneering platform companies and large pharma partners. We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest of scientific and ethical standards. Strong communication skills and comfort working in a dynamic and cross-functional team environment are required.

Responsibilities:

• Represent the Biology function on drug discovery project teams, supporting assets across diverse therapeutic areas/modalities including oncology, inflammation and metabolic therapeutic areas
• Identify and implement preclinical models that reflect patient pathology and develop assays to support in vitro assessment of lead small molecules, antibodies, peptides and genetic modalities
• Participate in partnerships and collaboration efforts with Flagship Platform companies and external pharmaceutical partners
• Support research operational workstreams, such as data/compound/lab management, in collaboration with cross-functional research leaders
• Management of direct report/s
• This position is on-site/hybrid in Cambridge, MA

Required Qualifications & Experience

• Ph.D., in Biology, Biochemistry or related field with 8+ years of relevant pharmaceutical/biotechnology experience
• Extensive experience in assay development and proficiency in drug discovery and development, including delivering data and documentation supporting IND/CTA regulatory filings
• Proven leadership and excellent mentorship skills, with experience in managing a team and leading programmatic matrix teams
• Scientific experience working in oncology, inflammation or metabolism drug discovery and development programs
• Ability and interest to work across multiple therapeutic areas and modalities
• Ability to effectively communicate complex scientific concepts and data to both scientific and non-scientific colleagues

Preferred Qualifications

• Experience performing scientific due diligence on assets and/or platform biotechs
• Experience working on cross-industry collaborations 
• Experience establishing processes for lab operations, including compound management

What We’ll Offer You

• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid flexible time off, 401k retirement plan, disability and life insurance, mental health program via Calm, backup care for children/senior and fully covered parking/commuter benefits.
• A dynamic work environment with entrepreneurial spirit and highly interdisciplinary, talented, and collaborative team. Opp