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Associate Principal Scientist, Analytical R&D

MSD
South San Francisco, United StatesRemotefull_timeVerifiedPosted 7 Jan 2026
💰 $246,300/yr($156,500/yr$246,300/yr)

About the role

Job Description

Join our Discovery Analytical Research group to drive innovation in analytical measurement technologies, enabling the discovery of new drug candidates across diverse modalities. The Discovery Analytical Research group within Analytical Enabling Capabilities (Analytical R&D) is seeking applicants for an Associate Principal Scientist position available at our research laboratories located in South San Francisco, California.

The successful candidate must be able to collaborate in a dynamic, integrated, and multidisciplinary team environment. A broad range of tools (e.g. high-resolution mass spectrometry, chromatography, spectroscopy) are leveraged, and new technologies are developed to influence selection of new drug candidates and enhance scalability and robustness.

Primary Responsibilities:

  • Enable discovery partner groups with advanced analytical methods

  • Represent the discovery analytical research group in project teams, provide technical guidance, and drive scientific strategy

  • Develop, implement, and troubleshoot advanced analytical methods (e.g., high-resolution mass spectrometry, liquid chromatography, capillary electrophoresis, ion chromatography, size exclusion chromatography, and two-dimensional techniques)

  • Solve complex problems and explore new measurement technologies

  • Collaborate in multidisciplinary teams, foster partnerships with discovery groups, and contribute to organizational goals

  • Support junior scientists and promote a culture of learning and innovation

  • Ensure high standards of data integrity and documentation

Qualifications:

Education: 

  • Bachelor's (with 12 years), Master's (with 8 years) or Ph.D. (with 4 years) in Analytical Chemistry or related field and relevant experience

Required Experience and Skills: 

  • Strong background and extensive hands-on experience in high-resolution mass spectrometry of large molecules (Proteins, mAb, ADC, etc.) and separation science techniques

  • Demonstrated scientific ability through publications in peer-reviewed journals and presentations in scientific conferences

  • Excellent verbal and written communication skills, demonstrated creativity, and strong interpersonal skills 

  • Ability to deliver complex objectives under challenging timelines in a rapidly changing environment

  • Ability to work in a team environment with cross-functional interactions

Preferred Experience and Skills:

  • Knowledge of biochemistry and organic chemistry

  • Experience with electronic laboratory notebook applications and good documentation practices

#EligibleforERP

Required Skills:

Analytical Chemistry, Antibody Drug Conjugates (ADC), Biologics, Chemistry, High Resolution Mass Spectrometry (HRMS), Mass Spectrometry Analysis, Protein Chemistry, Separation Sciences

Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal righ

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MSD

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