Cryo-EM Facility Manager

We are looking to hire a Cryo-EM Facility Manager to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods.

Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Ten of the programs we’ve worked on have progressed into preclinical development with four currently in clinical trials and one approved by the FDA.

This position will be based in the Greater Boston area at our new facility in Framingham, MA, which will house a Thermo Scientific Glacios 2 Cryo-TEM equipped with a Falcon 4i Direct Electron Detector and Selectris Imaging Filter.

Who will love this job:

• A cryo-EM expert who’s eager to push the boundaries of the technology, from sample prep through data collection strategies and computational image analysis
• A passionate scientist who’s excited about broadening the applicability of cryo-EM in enabling structure- and computation-driven drug discovery programs

What you will do:

• Work in a state-of-the-art structural biology team of 20+ structural biologists, protein scientists, and biophysicists with fully integrated gene-to-structure capabilities
• Oversee the operation, maintenance, and scheduling for our Glacios and associated equipment (including our Vitrobot Mark IV and Leica Plunge Freezer EM GP2)
• Train and supervise new users
• Collaborate with the cryo-EM team in the optimization of sample preparation (from construct design through vitrification), data collection, and data processing workflows 
• Lead the adoption and development of new technologies for single-particle analysis, tomography, and microED applications
• Interface with drug discovery and scientific development teams to drive projects forward with the use of our internal cryo-EM technology
• Build and maintain relationships with instrument service engineers and external cryo-EM service providers

What you should have

• MS or PhD in structural biology, biology, biochemistry, bioengineering, biophysics, chemistry, materials science, or a related discipline
• At least three years of experience managing a cryo-EM core facility, acting as a cryo-EM service engineer, or serving as a cryo-EM application scientist
• Deep knowledge of high-resolution structure determination of biological samples by cryo-EM, from sample vitrification to data collection and image analysis
• Extensive hands-on experience in cryo-TEM instrument operation, maintenance, and troubleshooting
• Experience setting up high-throughput computational workflows for single-particle analysis

  Pay and perks: Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work for the past three years running.   Sound exciting? Apply today and join us!   As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or p