Sr. Scientist, Biological Research

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About J&J Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

**There is a pre-identified candidate for this position; however, all applications will be reviewed.**

About the position:

The Senior Scientist will join a drug discovery team developing groundbreaking and best-in-class therapeutics for the treatment of prostate cancer. They will be a key contributor towards advancing research programs through various stages of preclinical drug discovery. This is a laboratory-based position requiring high productivity, effective and frequent collaboration with colleagues within the oncology group and other various cross-functional groups in the organization. This position requires versatility, strong communication skills, and ability to work in a fast-paced environment and high-level alignment with the Team leadership.

Key Responsibilities:

In this role, you will:

• Design and execute sophisticated in vitro experiments, and interpret data for validation and characterization of new therapeutic agents and targets to progress programs

• Support the generation of comprehensive and well-designed pre-clinical data packages in support of various programs, including for IND readiness for First-In-Human (FIH) studies

• Routinely perform cell biology techniques. Experience in cell culture, characterization of cell lines/tissue lysates by western blotting/qPCR/etc, cell proliferation assays including Incucyte-based assays, flow cytometry/FACS, CRISPR gene knockout and Lentiviral transduction of stable cell lines, cell imaging and other functional assays, etc. is needed.

• Analyze, prepare, and present data to internal stakeholders and project teams

• Work independently and perform multiple experiments simultaneously to generate robust data packages and align with scientific strategies and demands.

• Contribute to various projects outside of their own, and collaborate with team members from all relevant functions

• Keep up to date with the literature related to the field of prostate cancer

• Demonstrate clear and professional verbal and written communication

Required:

• PhD with relevant postdoctoral/ industry experience in drug discovery/novel target Id and validation

• Strong cell biology and assay development skills are required

• A robust background in cancer biology and drug discovery is required

• Previous experience screening and characterizing biologic and small molecule leads is required

• Proficiency with software such as GraphPad Prism, FlowJo, and Microsoft Office is required

• Detail-oriented, with strong problem-solving skills, attention to detail, excellent organizational and record-keeping skills

Preferred:

·       Experience in Prostate cancer research is preferr