Senior Scientist, Conjugation

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines and vaccines to patients around the world.

What You Will Achieve

As a Senior Scientist in the Early Bioprocess Development within Pfizer Vaccines, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include development of new/novel conjugation methods, analysis of glycoconjugates, and optimization of conjugation process parameters including conjugation and purification. Experience in the preparation of glycoconjugates is highly desired. The individual will become a key contributor towards the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

How You Will Achieve It

• Develop, optimize and scale-up conjugation process for glycoconjugate vaccine candidates.

• Independently plan and execute experiments for conjugate vaccine candidates, and lead the development on special projects, when required.

• Present periodic status updates to the group, discuss problems and propose solutions in discussion with group members. Offer insights based on experience to group members to help solve problems.

• Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess, Analytical, and Formulation Development groups.

• Keep abreast of scientific/technological development by participating in scientific meetings/seminars and through regular scientific review. Utilize new technologies and establish those technologies to improve conjugation process

• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, uses expertise and imagination to suggest improvements.

• Participate in the technology transfer of developed process to the clinical manufacturing site, both internally and externally, and provide the technical support as needed.

• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.

Qualifications

Must Have

• PhD degree in Organic Chemistry/Carbohydrate Chemistry or Biochemistry with 0 to 3 years of experience OR an MS degree in Chemistry with a 7 to 8 years relevant carbohydrate experience.

• Experiences with conjugation, purification processes and glycoconjugate analytical techniques

• Understanding of the design, planning, and execution of conjugation and purification activities including the operation and maintenance of relevant instruments, resolution of technical problems related to instruments, and execution of analytical/biophysical characterization methods.

• Experience with a variety of state-of-the-art analytical techniques including NMR, Mass Spectrometry etc. and other analytical techniques.

• Independently analyze and provide conclusions regarding experimental data generated.

• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

• Strong verbal and written communication skills are required.

• Experience with documentation of laboratory notebook in an electronic format.

Other Job Details

• Work Assignment: Onsite

  
 

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement