Senior Scientist, Bioanalytical Science

<p>Seaport Therapeutics is a clinical-stage&nbsp;therapeutics&nbsp;company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary&nbsp;GlyphTM&nbsp;technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass&nbsp;metabolism&nbsp;and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and&nbsp;are&nbsp;guided by an extensive network of renowned scientists,&nbsp;clinicians&nbsp;and key opinion leaders. For more information, please visit&nbsp;<a href="https://www.seaporttx.com/">www.seaporttx.com</a>.&nbsp;</p> <p>We are seeking an experienced scientist to take a key role in advancing preclinical discovery of its Glyph prodrug platform across a range of indications. The ideal candidate will have a roll up your sleeve’s mentality, contributing to a bioanalytical program to rigorously elucidate the functionality of a novel lipid prodrug platform and contribute to the selection of a program’s development candidates. This scientist may contribute beyond bioanalysis, i.e. expanding DMPK and ADME functions.</p> <p>The ideal candidate will embrace a collaborative, innovative culture that embodies our values of&nbsp;<em>service&nbsp;</em>to patients impacted by mental health conditions, with a&nbsp;<em>“we own it”</em>&nbsp;mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement. This position is based in Boston’s Seaport area and will be an in-office role 5 days a week and report to the Associate Director, Bioanalytical Sciences.</p> <p><strong>Responsibilities: &nbsp;</strong></p> <ul> <li>Support the development and optimization of bioanalytical methods (e.g. LC/MS) to evaluate concentration of API, metabolites, and related species across multiple small and large animal species</li> <li>Manage execution of method development and sample analysis across multiple external CROs and collaborators</li> <li>Assist in design and selection of methods of sample extraction and analysis across a range of matrices including lymph, plasma, and solid tissues</li> <li>Perform pharmacokinetic analysis of data, communicate results, provide scientific interpretations and recommendations to cross-functional project teams and leadership</li> <li>Contribute to the development or application of relevant pharmacokinetic models to add funda