Scheduled Hours

40

Position Summary

The Miriam Kim Lab studies methods to manipulate immune cells for treatment of hematologic malignancies. We work at the intersection of hematopoiesis, immunology, cancer biology, stem cell biology, and gene engineering.

We are seeking motivated individuals to assist with studies investigating the optimal host environment to support chimeric antigen receptor (CAR) T cell therapy. CAR T cells are genetically engineered immune cells that are used to treat patients with hematologic malignancies such as leukemia, lymphoma and multiple myeloma. While CAR T cell therapy has demonstrated impressive success, many patients do not benefit from treatment, and so we are actively looking for ways to improve outcomes. The successful candidate(s) will conduct preclinical studies using mouse models to assess the effect of immunomodulatory agents on CAR T cell expansion, toxicity and anti-tumor activity and their mechanism of action.

Prior research experience is welcome but not required for this position. The ideal candidate will possess intrinsic motivation to conduct innovative and impactful research. A growth mindset and ability to learn new concepts and skills is essential. The individual will be trained to perform experiments independently and analyze data to produce graphs and figures for publication. Career development opportunities may also be provided.

Routine laboratory techniques in our lab include:

* Isolation of primary immune cells from human and mouse samples, including monocytes, T cells, B cells, NK cells, and hematopoietic stem cells.
* Genetic manipulation of immune cells using lentivirus, retrovirus, and/or CRISPR/Cas9-based gene editing.
* Flow cytometry including sample preparation, acquisition and data analysis.
* Mouse husbandry and small animal procedures.

Assists with the technical aspects of studies and experiments, including documentation and preparation of materials.

Job Description

Primary Duties & Responsibilities:

• Assists with research studies, experiments and assays, including collection of data, preparation of solutions and setup and maintenance of equipment.

• Performs data entry and maintains data files on research.

• Prepares tissue cultures, reagents, probe tests, etc.

• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.

• Ensures lab conditions and equipment are properly cleaned and maintained in accordance with established procedures.

• Assists with general lab maintenance and cleaning.

• Performs other duties as assigned.

Working Conditions:

• This position works in a laboratory environment with potential exposure to biological and chemical hazards. 

• The individual must be physically able to wear protective equipment and to provide standard care to research animals.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education:

Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Certifications:

No specific certification is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

More About This Job

The ideal candidate will have up to one year of experience in a laboratory setting.

Preferred Qualifications

Education:

No additional education beyond what is stated in the Required Qualifications section.

Certifications:

No additional certification beyond what is stated in the Required Qualifications section.

Work Experience:

No additional work experience beyond what is stated in the Required Qualifications section.

Skills:

Communication, Detailed Reports, Laboratory Instrumentation, Laboratory Research, Software Program, Working Independently

Grade

R06-H

Salary Range

$16.92 - $26.44 / Hourly

The salary range reflects base salaries paid for pos