Senior Scientist

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP’s Commitment to Diversity, Equity, and Inclusion

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. We strongly encourage candidates of all races, colors, ethnicities, religions, perspectives, sexes, backgrounds, and lived experiences to apply.

A Brief Overview
Principal contributions are scientific or intellectual, characterized by originality and creativity. May work with the mentorship of an established principal investigator to conduct research in a specific scientific area. Initiates and conducts independent experiments without direct supervision and with minimal guidance from the principal investigator. Develops new experimental procedures and publishes research results. Collaborates and interacts with other researchers within CHOP – RI and at other institutions. Develops new experimental procedures and hypotheses for further investigation. Prepares manuscripts and abstracts for publication. Publishes scientific articles in refereed journals, presents at scientific symposiums. Prepares grant proposals for external funding. Serves as resource person for colleagues and as a mentor for less experienced research personnel. Manages/supervises other research staff or projects and assists with the management of laboratory operations.

About the Laboratory

We are seeking a highly skilled Senior Scientist to join Dr. William Peranteau’s laboratory. The successful candidate will play a key role in the design and execution of in utero gene-editing experiments utilizing CRISPR-based technologies, adeno-associated virus (AAV) vectors, LNP formulation, flow cytometry, next-generation sequencing (NGS), and more to advance our research objectives. This position requires a strong foundation in molecular and cellular biology, with proven hands-on experience at the bench and with animal models including mice and sheep. Experience with Prism, Flowjo, and Snapgene a plus. In addition to leading independent research projects, the Senior Scientist will be responsible for training and mentoring postdoctoral fellows, graduate students, and other trainees, fostering a collaborative and educational lab environment. The ideal candidate will demonstrate scientific rigor, strong communication skills, and a commitment to advancing translational gene-editing research.

https://www.chop.edu/doctors/peranteau-william-h

https://www.research.chop.edu/people/william-h-peranteau

What you will do

• Conducts research of significant scientific value in the basic and/or translational science area(s)
• In collaboration with the PI functions independently in the development and execution of research projects
• Initiates and maintains collaborations with researchers, external agencies and institutions to develop cooperative research initiatives
• Trains technical staff, students, fellows, physicians in lab procedures and compliance
• Supervises students or other research staff to ensure correct procedures are followed
• Provides general supervision over the laboratory or research group
• Assists in management of resource allocations and day-to-day lab personnel activities
• Composes high quality publications for peer reviewed, scientific journals
• Participates in procurement of additional