Principal Scientist - On-site Marlborough, MA

Sartorius’ Emerging Therapies Services team in the Greater Boston (MA) area is a part of Corporate Research Group and is engaged in the design, development, and optimization of iPSC engineering and manufacturing processes that can be transformed from early pre-clinical stage into cGMP ready manufacturing scale. As the Principal Scientist, you will be expected to work closely together with an internal multi-disciplinary product development team, to create forward looking processes that provide a basis for commercial manufacturing that can be integrated into our process solution offering. 

Sartorius is seeking an individual with drive, and passion, to be part of a newly developed team based in our Marlborough, MA office.  As part of the Corporate Research team, you will lead design and optimize protocols for the differentiation of iPSCs into specific cell types using cutting-edge techniques. 

If you are interested in joining a company known for a great culture, innovative technologies and potential for career growth opportunities then please read on.

To drive the creation of new innovative biomanufacturing solutions, Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next generation continuous and integrated closed manufacturing solutions. This exciting initiative enables the research, process development and clinical production of novel modalities using next generation manufacturing platforms, in partnership with key customers.

What you will accomplish together with us:

• You will design and optimize protocols for the differentiation of iPSCs into specific cell types using cutting-edge techniques aimed at enhancing the efficiency and scalability of the differentiation processes.
• One of your tasks will be to lead cross-functional teams, to scale iPSC expansion and differentiation from benchtop to production scale bioreactors.
• You will develop and write process development proposals, conduct hands-on laboratory work to optimize and troubleshoot upstream and downstream manufacturing processes for  iPSCs and iPSC derived cells and tissues.
• In this role, you will analyze and interpret data ensuring clear documentation of methodologies and outcomes.
• You will prepare detailed reports and presentations for internal and external partners to communicate progress in line with project schedules.
• You will assist in mentoring and training junior team members and coordinating the day-to-day operations.
• Your duties will include leading and managing multiple high impact internal and external research projects by establishing priorities, milestones, schedules, and deadlines.
• You will be responsible for writing, reviewing, and maintaining electronic lab notebooks with the highest level of research integrity.
• You will be responsible for writing project reports, briefs, protocols and making presentations to internal and external partners and project teams as required.
• In this role, you will lead technology transfer activities to internal and external collaborators.
• You will support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
• Your tasks include conducting technical investigations and risk assessments related to processes.
• Support marketing efforts by writing technical briefs, application notes and peer reviewed publications, leading or assisting with technical presentations at scientific conferences.
• Support generation of protocols, work instructions, batch records and reports.
• Work independently in a matrixed environment.
• Perform occasional extended hours and weekends to support ongoing lab activities as needed.
• On an as needed basis, you will mentor and support junior staff and build a culture of support and collaboration.
• Comply with all site policies such as record retention, ISO requirements, and accountable for good housekeeping in all laboratories.
• Comply with biohazard, special clean room and site safety/health procedures and guidelines as required.
• Assist other team members and site management team with miscellaneous duties when requested.

What will convince us:

Education:

• You possess a Ph.D. (with 6+ years of industry experience) in chemical, biochemical or biomedical engineering, engineered cell therapies or related field.

Experience:

• Extensive expertise in generating, differentiating, expanding and characterizing pluripotent cells and their derivatives.
• Expertise in differentiating pluripotent cells into multiple clinically relevant lineages in planar and bioreactor systems.
• Hands-on e