Scientist III/Senior Scientist, Immunology Sciences

The individual hired into this role will participate in a research group focused on investigative Immunology and the development and method transfer and/or in house implementation of Immunological assays that support Kriya’s current and exploratory programs.  This includes the development, optimization, potential qualification, and execution of assays in support of non-clinical and clinical development of AAV-based products or evaluation of novel models and assays designed to evaluate immunogenicity or pharmacokinetic/pharmacodynamic profiles. Clinical and/or non-clinical sample analysis experience or clinical biomarker assay development/translational sciences experience is required. Experience in one or more immunologic assay type including but not limited to experience in ex vivo cell based assays and evaluation of immune responses or marker expression by either flow cytometry, immunocytochemistry, or immunohistochemistry is required. Additionally, this role will oversee a small team of scientists that will develop methods and data to support immunology-based questions or identify potential biomarkers in support of Kriya’s pipeline. The ideal individual for the role will be highly organized with attention to detail and a passion for learning and be highly adaptable.  This individual will work closely with other team members to execute the assays and support data analysis and presentation as needed.  This role will provide the individual the opportunity to grow and develop while advancing Kriya’s pipeline from research into clinical phase development.

How You Contribute

• Lead biological project to implement, develop and qualify immunological assays including but not limited to ELISA, MSD, immunocytochemistry, fluorescent microscopy and flow cytometry under direction of project leader.
• Conduct non-clinical and clinical sample analysis as directed in support of pharmacology and translational studies to support program stage gate decision making
• Help identify or evaluate potential biomarkers in support of Kriya’s pipeline targets
• Assist and may lead assay transfer to contract research organizations (CROs) and/or other labs in support of nonclinical and/or clinical studies
• Perform data analysis using appropriate software (such as SoftMax, Prism, etc.)
• Responsible for documentation of all project work in appropriate electronic and/or paper-based laboratory systems
• Responsible for reagent sourcing, receipt, storage, inventory and preparation as directed
• Responsible for maintenance of laboratory instrumentations as directed
• Collaborate with other scientists and routinely present data
• Maintenance of updated safety, compliance, and SOP training
• Ability to work in a fast-paced team-oriented setting with good communication skills

What You Bring to the Team

Education & Experience

• Senior Scientist 
  • Degree in immunology, biochemistry, or relevant discipline plus relevant working experience (years) in a pharmaceutical/biotechnology or CRO laboratory setting:
    • Bachelor’s degree with 12+ years’ work experience
    • Master’s degree 10+ years’ work experience
    • PhD degree or equivalent with 7+ years’ work experience
• Scientist III
  • Degree in immunology, biochemistry, or relevant discipline plus relevant working experience (years) in a pharmaceutical/biotechnology or CRO laboratory setting:
    • Bachelor’s degree with 10+ years’ work experience
    • Master’s degree 8+ years’ work experience
    • PhD degree or equivalent with 5+ years’ work experience 

Competencies

• Hands-on experience in cell-based assay method development, non-clinical or clinical sample analysis, particularly in evaluation of immune responses and biomarker assays 
• Experience with mammalian cell culture including transduction and transfection of cell lines and primary cells or isolation of cell populations
• Must be highly organized with attention to detail
• Excellent written and oral communication skills
• Highly adaptable to changes and fast-paced setting 
• Positive attitude with a solutions-based approach to challenges
• Experience with mammalian cell culture a must
• Experience with neurological, metabolic, and/or ocular in vitro models is preferred
• Experience with flow cytometry, immunohistochemistry, fluorescent microscopy, or immunoassays is preferred

Working Conditions and Physical Demands

• Work is normally performed:   at a desk and laboratory environment
• Lifting requirements:   Over 20 lbs
• Travel requirements:   Occasional 
• Must be willing to work at