Postdoctoral Fellow-MSH-32035-050

We are looking for a Postdoctoral Fellow with a strong background in molecular and cellular biology, as well as protein biochemistry. The ideal candidate will have experience working with both cell culture and animal models. Experience in metabolism and epithelial cell biology is an advantage. The candidate should have completed their PhD within the last 1 to 1.5 years.

Appointment Term (and whether reappointment is possible): 09/2024-09/2025 with yearly reappointment

Location of appointment: Annenberg 18-10, Mount Sinai

Lab and department websites:  https://icahn.mssm.edu/research/domi

Wages or salary; and benefits: $78,000 +Fringe benefits and additional UAW negotiated postdoc benefits.

Lab of Dr. Prashant Rajbhandari in the Diabetes, Obesity, and Metabolism Institute (DOMI) has an opening for postdoctoral position. Rajbhandari Lab is broadly interested in 1) Immune cell regulation of lipid metabolism (Cell 2018), 2) developmental process of brown/beige and white fat, and 3) mammary gland adipose biology (Nature 2023), and 4) crosstalk between adipose and other metabolic tissues (esp liver) in the setting of obesity (Nature Medicine, Cell Metab 2017,2018). To address these topics, the lab uses cell and molecular biology, biochemistry, Next-gen sequencing (ChIP-, RNA-, ATAC-seq), animal model, single cell/nuclei RNA sequencing, and imaging. The broader significance of the work in Rajbhandari Lab is that obesity is linked to various diseases and by studying how cellular and molecular pathways are perturbed in the setting of obesity might provide better understanding of this disease. 

We are looking for a Postdoctoral Fellow with a strong background in molecular and cellular biology, as well as protein biochemistry. The ideal candidate will have experience working with both cell culture and animal models. Experience in metabolism and epithelial cell biology is an advantage. The candidate should have completed their PhD within the last 1 to 1.5 years.

Essential Duties and Responsibilities                                                                                              

1. Advanced skills in Molecular Biology techniques 
2. Advanced skills in cell biology, protein biochemistry, mass-spec, immunoblotting, immunohistochemistry, mRNA in situ hybridization, confocal imaging, cell culture, etc
3. Advanced skills in Animal handing and measuring metabolic physiology in mice
4. Mammalian cell culture techniques.
5. Animal handling, colony management, and genotyping
6. Eager to learn new techniques, operate and manage lab equipment and personnel
7. Next gen sequencing, cRNA-Seq expertise is not required but preferred. 

• Design and conduct experiments in molecular and cellular biology, protein biochemistry, and related areas.
• Work with cell culture systems to study cellular processes and protein function.
• Utilize animal models to investigate biological mechanisms and validate experimental findings.
• Analyze and interpret data, and present findings at lab meetings and conferences.
• Collaborate with other team members to achieve research goals.
• Prepare manuscripts for publication in peer-reviewed journals.

Remarks or Special Instructions
Additional Preferred Expertise and Skills (not required):

Advanced skill in adipose biology.

Advanced intracellular signaling pathways.

Advanced flow cytometry, cell sorting

Experience with adeno-, lenti-, and or AAV viral vector generation.

Experience with coding languages such as R.

Applicants must hold a Ph.D. or equivalent terminal degree in a relevant field by the start date and have research interests aligning with our department’s objectives. A complete application includes a comprehensive CV, over letter, a detailed research proposal (if required), and at least three recent letters of recommendation from academic or professional mentors highlighting the candidate's research capabilities and suitability for the role. Candidates should demonstrate a strong record of relevant research experience, evidenced by publications and proficiency in relevant methodologies and technologies. The evaluation process involves an initial screening for eligibility, a thorough review of application materials by a faculty committee, and interviews for shortlisted candidates, which may include a research presentation. The final selection considers the candidate’s fit with the department’s goals and ongoing projects, aiming to recruit individuals who show exceptional promise and dedication to advancing their field.

Compensation Statement

The Mount Sinai Health System (MSHS) provides a s