Associate Principal Scientist, DMPK Protein Therapeutics Modeling

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Associate Principal Scientist to contribute to our company's modeling and simulation capabilities for small molecule, peptide and protein therapeutic drug discovery and early clinical development efforts.  This position will be based at our research labs in Boston, MA.  The ideal candidate will contribute to collaborative PDMB modeling and simulation efforts as a translational PK/PD subject matter expert, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our company.  Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well.  The successful candidate will be expected to represent PDMB on cross-functional teams through generation and interpretation of translational modeling and simulation strategies as well as through effective communication at both internal meetings and external conferences. 

In this exciting position, your primary roles will include:

• Incorporation of in vitro and in vivo data into systemic models of drug disposition, pharmacodynamics and efficacy in support of translational and reverse translational pharmacology efforts across multiple modalities and therapeutic areas

• Design and optimization of novel model structures utilizing state-of-the-art modeling software to understand the impact of drug disposition on novel disease biology and pharmacological response (PK/PD) with an aim of informing on human PK and dose projections

• Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient modeling and simulation strategies to identify and optimize drug candidates

Education Minimum Requirement

• Ph.D (with 3+ years relevant experience), Master’s (minimum of 6 years relevant experience), or Bachelor's (minimum of 10 years of experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field

• Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting

Required Experience and Skills

• Experience contributing to development, execution, and fostering of translational and/or reverse translational pharmacokinetic-pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery or development

• Hands-on experience with translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB, etc

• Technical ability to analyze, interpret and provide context around data describing the pharmacokinetic and pharmacodynamic properties of novel therapeutics, ensuring relevance to known or emerging biology around a given drug target

• Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment

Preferred Experience and Skills

• Expertise in biologics/large molecule/protein therapeutics DMPK modeling

• Proven track record supporting immunology or oncology-based programs with experience spanning from early