Executive Director, Global Market Planning and Operations

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Title: Executive Director, Global Market Planning and Operations

Department: Global Marketing

Location: Conshohocken, PA or Waltham, MA (hybrid)

About Madrigal Pharmaceuticals

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Description

The Executive Director, Global Market Planning & Operations is responsible for driving operational excellence/efficiency across the U.S. marketing team and guiding global strategic brand and asset planning. This role will oversee execution of key cross-marketing initiatives and will orchestrate global strategic planning for Rezdiffra and development assets. This global marketing leader will partner closely key stakeholders across the U.S. and global teams in commercial, medical and R&D to optimize planning and execution.

Key Responsibilities

1. Marketing Operations Leadership

• Identify, centralize and lead tactical execution of key U.S. marketing initiatives in close collaboration with HCP and DTC marketing functions, including both not limited to operations supporting HCP congresses, HCP speaker/patient programs, and sales force fulfillment.
• Serve as Promotional Review Committee (PRC) chair responsible for driving decision making at monthly and ad hoc PRC leadership committee; drive process improvements - inclusive of appropriate integration of AI - to drive consistency and efficiency of promotional reviews.

• Lead annual cross-functional Global brand planning process in collaboration with U.S., Global and International teams in Commercial, Medical, HEOR, Legal, Regulatory and Finance.
• Collaborate with HCP, DTC marketing and Strategy/Ops team to develop a holistic brand view on NPP (and in future omnichannel state) spend, ROI, and efficiency across channels.

2. Market Planning leadership

• Serve as the commercial representative at program teams for development assets, providing commercial input into established program teams including but not limited to guide target product profiles (TPPs) development, clinical development plans, and key asset go/no-go decisions.
• Partner closely with Commercial Strategy and Operations (CSO) team in aligning on customer insights and market research to drive assumptions on TPP development, commercial forecasting/valuations and scenario analyses to support R&D investment decisions.
• Own the early brand strategy and positioning for