Senior Scientist, Translational Modeling & Simulation

Use Your Power for Purpose

At Pfizer, we deliver breakthroughs that transform patients' lives. Your work will directly impact the development of innovative therapies and vaccines, ensuring that we continue to deliver top-tier medicines to patients globally. By leveraging advanced science and cutting-edge technologies, you will help expedite the delivery of impactful treatments, improving the lives of patients around the world.

What You Will Achieve

The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer’s Department of Pharmacokinetics, Dynamics and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PK/PD, PBPK, QSP) to influence decision making from project ideation through early clinical development.   Emphasis will be in the diverse areas of internal medicine and inflammatory/immunological disorders, and include both biologics and small molecule modalities.

This role primarily involves interaction with other members of multidisciplinary project teams includng Biology, Medicinal Chemistry, BioMedicine Design, PDM, Drug Safety, Pharmaceutical Sciences, Clinical Pharmacology, and Clinical.  Interaction with internal and external modeling and simulation experts is also expected.

How You Will Achieve It

In this role, you will:

• Work closely in multidisciplinary project teams to develop and implement appropriate mathematical models (mechanistic, semimechanistic, empirical) of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design.
• Collaborate with research biology to help in the development of in vitro assays and in vivo models to generate data that inform preclinical-to-clinical, translational PK/PD models.
• Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies.
• Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
• Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventionalmodalities.
• Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences.
• Continue to build a personal track record of publication in the area of PK/PD modeling and simulation and contribute to PDM’s external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation.

Here Is What You Need (Minimum Requirements)

• Ph.D. degree or equivalent degree in systems biology, pharmacometrics, pharmaceutical sciences, engineering, physics, mathematics, or similar disciplines where modeling and simulation is emphasized; experience with modeling of biological systems is strongly preferred.
• 0 – 2 years of relevant experience in the pharmaceutical industry.
• Strong communication skills, ability to work independently and in teams, and attention to detail.
• Good team player and communicator; including good listening skills and the ability to effectively interact with colleagues with a variety of backgrounds.
• Self-starter with demonstrated ability to work in a small team with minimal technical supervision.
• Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modeling and simulation.
• Ability to translate/condense/summarize outcomes of modeling and simulation analyses into information that can be understood by non-experts.
• Hands-on knowledge of the state-of-the-art modeling and simulation software and applications in the area of PK/PD modeling and simulation (e.g. NONMEM, MatLab, Phoenix, Berkeley-Madonna, SAAM II, ADAPT, ACSL, S-plus, R or comparable applications).
• An understanding of the basic principles of pharmacokinetics (e.g. non-compartmental, compartmental, PBPK).
• Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically-relevant PK/PD models.
• Ability to keep up-to-date with and propose the implementation of scientific and technological developments in the area of PK/PD modeling and simulation.
• Motivation to develop a career as a hands-on, technical modeling and simulation expert in a preclinical