Director/Sr. Director, Business Development & Operations

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on
 
In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. 
 
Together we define white space, push boundaries and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma.

Affiliate Overview

Calcilytix Therapeutics, an affiliate within BridgeBio Pharma, is developing encaleret, a negative allosteric modulator of the calcium-sensing receptor (CaSR) for the treatment of Autosomal Dominant Hypocalcemia Type 1 (ADH1), a genetic cause of hypoparathyroidism. Encaleret is currently being evaluated in a Phase 3 clinical study and has received Orphan Drug Designation from the US FDA, EMA, and PMDA as well as Fast Track Designation from the US FDA. Results from the Phase 2b clinical study of encaleret in patients in ADH1 were published in the New England Journal of Medicine.

What You'll Do

As the Director/Sr. Director, Business Development & Operations, you will play a key role in shaping the future direction of our Encaleret program. You will lead strategic planning efforts and provide critical insights that influence high-impact decisions. Your expertise will help guide commercial launch readiness, modeling & forecasting, preparation of corporate materials intended for presentation, corporate development, and strategic activities. You will also partner closely with cross-functional teams, including supply chain and operations, to ensure strategic alignment. Your analytical skills and industry experience will directly contribute to the company’s long-term success.

Responsibilities

Strategic Planning and Execution

• Shape and communicate the company’s strategic direction through well-structured presentations that guide prioritization and resource allocation
• Lead strategic analyses for program evaluation, including discounted cash flow modeling, and secondary research (e.g., analogs research, epidemiology, claims data analysis)
• Prepare a strategy to guide the successful US commercialization of encaleret

Stakeholder Communication

• Develop and deliver executive-level PowerPoint presentations that effectively communicate strategic insights, corporate initiatives, and market analyses
• Create high-quality visual materials for leadership offsites, Board of Directors meetings, investor discussions & communications, and internal alignment efforts
• Ensure presentations are tailored to the audience, synthesizing technical and business content into clear, concise, and actionable messaging
• Present and discuss findings of strategic analyses to a variety of audiences, including the Calcilytix team, leadership, and investors
• Support corporate development and partnering strategy to ensure that Encaleret can be accessed by patients worldwide

Supply Chain & Manufacturing Partnership

• Partner with Technical Operations and CMC teams to assess long-term supply chain capabilities and infrastructure needs
• Develop strategic analyses related to contract manufacturers (CMOs), raw material sourcing, and distribution logistics
• Contribute to make-vs-buy decisions, cost optimization, and supply chain resilience planning, especially as pipeline products move toward commercialization

Cross-functional Partnership

• Collaborate with R&D, Regulatory, Finance, Commercial, and Operations to ensure holistic strategy development
• Collaborate with functional experts as a strategic partner to support the clinical and commercial success of Encaleret
• Collaborate with the BridgeBio commercial team and oversee research in pricing and reimbursement
• Lead or contribute to special initiatives involving product lifecycle planning, global expansion, or operational efficiency

Where You'll Work

This is a hybrid role and requires in-office collaboration at least 2-3x per week in our San Franc