Senior Scientist, BioDesign, BioTherapeutics Discovery

Job Description

About This Role

The Senior Scientist role in the Biotherapeutics Discovery and Delivery group within BioDesign will collaborate closely with CROs and external partners to deliver high-quality therapeutic candidates efficiently. Leveraging expertise in antibody engineering principles, structure, and characterization, you will strategically guide antibody discovery and optimization. This role also involves designing and developing antibody-oligonucleotide and protein fusion therapeutics, utilizing machine learning techniques for hit triage, lead optimization, and identification of sequence liabilities. Extensive cross-functional collaboration is essential for advancing novel antibody therapeutics into the pipeline. Your strategic vision, innovation focus, and effective execution will significantly impact Biogen’s biologics capabilities.

What You’ll Do

• Manage external antibody discovery through CROs and collaborative partnerships
• Strategically apply antibody engineering and optimization approaches
• Conduct antibody developability assessments
• Collaborate with internal and external partners with machine learning expertise to apply ML strategies for hit triage, lead optimization, and identifying sequence liabilities
• Design and develop antibody-oligonucleotide and protein fusion therapeutics
• Oversee project timelines and deliverables to ensure high-quality therapeutic antibody candidates
• Lead cross-functional teams to integrate antibody discoveries into pipeline programs
• Identify and implement strategic innovations within antibody discovery and engineering
• Interpret and oversee analysis of single-cell technology data (e.g., 10x Genomics)
• Maintain clear, effective communication with internal stakeholders and external collaborators
• Ensure thorough antibody characterization and rigorous quality control

Who You Are

You are a strategic thinker with deep expertise in antibody structure, engineering, and characterization, passionate about collaborating externally and driving therapeutic innovations. You excel in cross-functional leadership and have a proven track record of advancing complex biologics from discovery to the pipeline.

Qualifications

Required Skills

• Ph.D. in biochemistry, chemical biology, or a related field with 2-5 years experience, or a Master’s degree with 6-8 years relevant industry experience.

• Proven experience managing antibody discovery through external partnerships (CROs)

• Deep expertise in antibody developability assessment and engineering
• Proficiency with machine learning methods for antibody optimization, hit triage, and sequence liability evaluation
• Experience in designing antibody-oligonucleotide or protein fusion therapeutics
• Strong project management skills for delivering high-quality candidates on schedule
• Excellent communication skills for effective collaboration internally and externally
• Broad knowledge of antibody applications in therapeutic pipeline development

Preferred Skills

• Experience with single-cell technologies (10x Genomics) and/or display platforms (yeast).
• Familiarity with biologics data management and integration platforms

• Experience developing complex biologics such as bispecific antibodies, fusion proteins, or engineered scaffolds.

Additional Information

The base salary range for this position is $122,000 - $163,000. Base salary offered is determined though an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.  Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.   

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees and their families' physical, financial, emotional, and social well-being; including, but not limited to:  

• Medical, Dental, Vision, & Life insurances 
• Fitness & Wellness programs including a fitness reimbursement   
• Short- and Long-Term Disability insurance  
• A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31) 
• Up to 12 company paid holidays + 3 days off for Personal Significance 
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit 
• 401(k) program participation with company matched contributions