Senior Principal Scientist – DMPK Project Representative

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position Summary

We seek an innovative, self-motivated, exceptional scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) department at our Cambridge, MA site. The role is a senior scientific leader responsible for shaping DMPK strategy across oligonucleotide discovery programs from target validation through candidate selection. This role provides strategic leadership in ADME, pharmacokinetics, PK/PD, and translational science, influences compound design and progression, and represents DMPK on multidisciplinary teams to support high-quality decision-making across the portfolio.

Key Responsibilities

• Lead DMPK strategy for oligonucleotide discovery programs from early discovery through candidate nomination, identifying risks and enabling data-driven decisions. 
• Provide modality-specific expertise in oligonucleotide disposition, including tissue distribution, uptake, metabolism, stability, and exposure-response relationships. 
• Design and interpret in vitro and in vivo DMPK studies and integrate findings from bioanalysis, pharmacology, and toxicology to guide compound optimization.
• Apply translational and model-informed approaches to predict human PK/PD, dose, and regimen strategies for ASO therapeutics. 
• Represent DMPK on cross-functional teams, influence portfolio decisions, and mentor scientists while advancing innovative platform capabilities. 

Qualifications & Experience

• Ph.D. in pharmacokinetics, drug metabolism, pharmacology, or related discipline with 6+ years of industrial experience
• Deep expertise in ADME, PK/PD modelling with experience in Oligonucleotide / ASO pharmacokinetics and disposition
• Demonstrated ability to lead and influence drug discovery programs and candidate selection
• Excellent interpersonal, organizational, oral/written communication skills
• A strong team player with ability to collaborate and build trustworthy relationships with other disciplines for idea generation, issue resolution and program advancement

#LI-Onsite

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Cambridge Crossing: $194,710 - $235,942

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. 

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.
 

Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Cover