Research Associate, Compound Management

About Empress

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Founded by Flagship Pioneering in 2020, Empress Therapeutics generates good medicines, fast, by starting with chemistry inside the human body. The Empress Chemilogics™ platform uses novel insights that connect the lines of code in DNA with drug-like chemistry made in the human body to create first- or best-in-class oral medicines for a broad range of diseases quickly, predictably, and cost-effectively.

About the Position

Empress Therapeutics is seeking a Compound Management Research Associate to join our Platform Development in a role critical to the function of our Chemilogics platform.  You will be responsible for tracking the quality, quantity, location, and transfer of molecules within the physical company compound library and associated database. This position will collaborate with various teams to fulfill compound requests for dry and solution-based compound samples to be used in downstream biological function assays. Experience running HPLC and/or LCMS for quality control (QC) is preferred. You will demonstrate an attention to detail, have strong organizational and communication skills, and must be driven, resourceful, and able to work independently.

Key Responsibilities:

• Register CRO-generated and in-house purified compounds into our database and laboratory information management system(LIMS)
• Keep detailed and up-to-date compound inventory (solids and solutions), including physical stocks in the lab and digital documentation in an electronic lab notebook
• Prepare stock solutions and samples for internal and external assays, screens, and shipping to external partners
• Fulfill compound-related requests from research teams
• Coordinate the import and export of compound shipments and work with expeditor to ship, track, and ensure delivery
• Perform routine quality control (QC) on compounds used in biological assays
• Familiarity will Biochemical and Cell-based assays for compound function is desirable
• Develop compound management workflows and assist with chemistry-related tasks as needed
• Experience with Automation is a plus

Qualifications:

• Bachelor’s or Master’s degree in chemistry, analytical chemistry, chemical biology, biochemistry or related discipline

• Basic understanding of compound management principles and workflows
• Experience using HPLC and LC-MS platforms for quality control (QC)
• Experience with inventory/request database systems for compound and/or biological sample management (LIMS)

• Experience working in a lab environment, drawing and confirming chemical structures, and handling chemical solutions and powders
• In-depth understanding of small molecule stereochemistry
• Highly organized with an ability to keep accurate and detailed documentation.
• Self-driven and comfortable working with highly skilled teams in a fast-paced, entrepreneurial setting
• Ability to complete tasks in a timely manner, propose improvements to company workflows, and assist other teams with other projects as needed

What We’ll Offer You

• The opportunity to learn about all aspects of our drug discovery platform and variety of new skills including working with automation.   
• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
• A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
• Opportunities to invent and discover.

 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms,