Process Development Senior Scientist

Career Category

Process Development

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career

Process Development Senior Scientist.

What you will do

Let’s do this. Let’s change the world. In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at either our Thousand Oaks, California or Cambridge, Massachusetts campus. In this dynamic role, the individual will drive innovative solutions to support manufacturing of therapeutic peptides at various stages of development; pre-IND through commercial production. The successful candidate will have a strong background and experience in industrialization of solid phase peptide synthesis, ideally complemented with experience in peptide purification, isolation, and characterization techniques. The individual will be highly motivated and team-oriented with a proven track record of scientific innovation and achievement.

Responsibilities:

• Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to develop scalable synthetic processes utilizing solid phase peptide synthesis
• Drive technology innovation in solid-phase synthesis, purification, and characterization of synthetic peptides
• Support cGMP manufacturing and technology transfer to external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of solid phase peptide synthesis
• Work independently in advancing projects and studies within required deadlines.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR
Master’s degree and 3 years of scientific experience
OR
Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications:

• Ph.D. in organic chemistry, biochemistry, or chemical engineering with expertise in synthetic peptide process development
• Extensive hands-on expertise in the synthesis and purification of synthetic peptides produced by solid phase synthesis
• Experience within the pharmaceutical/biotech industry developing solid phase peptide synthesis processes and scaling/transferring the process into GMP manufacturing
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Familiarity with laboratory automation, data analysis and visualization techniques and tools
• Track record of peer-reviewed publications and research presentations
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• A research summary included with CV is strongly encouraged

What you can expect of us

As we work