Senior Scientist, PKPD Modeling & Simulation

The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer’s Department of Pharmacokinetics, Dynamics, and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PKPD, PBPK, QSP) to influence decision making from project ideation through early clinical development for both biologic and small molecule modalities. Emphasis will be in oncology with a particular focus on biologics but expand to small molecule project support and opportunities in other therapeutic areas such as immunology and inflammation, metabolic diseases, and infectious diseases. 

Responsibilities:

• Work closely with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, quantification of exposure-response relationships, biomarker characterization and early clinical trial design
• Collaborate with research biology in the development of in-vitro assays and in-vivo models to generate data that inform preclinical-to-clinical translational PKPD models
• Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies
• Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
• Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventional modalities
• Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences
• Continue to build a personal track record of publications in the area of PKPD modeling and simulation and contribute to PDM’s external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation

Basic Qualifications:

• Ph.D. degree or equivalent experience in pharmaceutical sciences, systems pharmacology, pharmacometrics, engineering, mathematics, physics or similar disciplines where modeling and simulation is emphasized.
• 0-3 years of pharmaceutical industry or related experience in developing and applying mechanism based PKPD models to guide project teams from early discovery to early clinical development
• Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
• Ability to effectively translate/condense/summarize outcomes of modeling and simulation analyses into useable information for multidisciplinary project teams
• Good team player and communicator that can effectively interact with colleagues with a variety of backgrounds
• Ability to work with on-site and remote colleagues
• Keen to interact as a modeling and simulation expert with matrix project teams working closely with within PDM as well as biology, protein engineering, chemistry, safety and clinical scientists
• Strong belief that modeling and simulation can have a significant positive impact on research projects
• hands-on knowledge of the state-of-the-art modeling and simulation software with (NONMEM, MATLAB, Monolix, Berkeley-Madonna, R or comparable applications)
• Ability to learn new areas of biological sciences and build on a solid foundation of quantitative skills to develop mechanistically relevant PKPD models
• Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation
• Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment
• Committed to sharing technical expertise and the development of self and others

Preferred Qualifications:

• Experience in working in the oncology disease area
• Pharmaceutical industry or related experience in developing and applying quantitative pharmacology models (e.g. PBPK, PKPD, QSP)
• Familiarity with biotherapeutic modalities
• Familiarity with dispositional and pharmacological aspects of either small molecules or biologics.

  

PHYSICAL/MENTAL REQUIREMENTS

office job involving use of computer; requires mental capacity to implement complex mathematical models

Relocation support available

Work Location Assignment: On Premise

The annual base salary for this position ranges from $88,300.00 to $14