Senior Scientist II or Principal Research Scientist I, DNA-encoded Library

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The DNA-encoded Library (DEL) platform group at AbbVie Headquarters in Lake County, Illinois, is seeking a highly talented and motivated scientist to enhance our DEL Chemistry development platform and DEL data analysis capabilities within our Small Molecule Therapeutics and Platform Technologies organization. The individual will work within our DEL Team and collaborate with cross-functional groups including medicinal chemistry, protein sciences, biophysics, and cheminformatics to drive AbbVie DEL platform developments. The successful candidate should possess strong communication and leadership skills and will be expected to contribute to various drug discovery projects across the therapeutic area portfolio of AbbVie interests.

Key Responsibilities:

• Be accountable for the design, development and validation of DELs synthesis schemes with high structural diversity using robust chemistry.
• Supervise efforts to develop, validate, and implement innovative on-DNA chemistry strategies. Provide technical supervision and expertise in standard and innovative synthetic methods as required.
• Interface with Medicinal Chemistry teams to enhance the DEL library portfolio, hit expansion strategy, and hit confirmation activities.
• Contribute to the development of computational tools and methodologies strengthen our DEL data analysis platform and support hit generation activities across AbbVie therapeutic area portfolio.  
• Contribute to the direction and evolution of AbbVie’s DEL platform strategy.

Qualifications

• BS, MS or Ph.D. in Computational Chemistry, Medicinal Chemistry, or related discipline with typically 4-6+ (PhD), 10-12+ (MS) or 12-14+ (BS) years of exp