Senior Scientist I – siRNA, Pipeline Development

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

Position Overview:

AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department in Cambridge, MA. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities:

• Lead research efforts within a cross-functional team to advance new extrahepatic therapeutic targets for siRNA -based drug discovery.
• Design and execute in vitro and in vivo proof-of-concept studies to assess target engagement, validate biological pathways and therapeutic benefits.
• Develop and optimize assays and tools to evaluate siRNA library for their delivery, efficacy, and off-target risks.
• Contribute scientific leadership and expertise in target biology, target selection and pipeline development.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
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