Contractor, Associate Scientist, Large Scale Protein Purification

About Generate Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received over $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role:

This is a full time Contractor role with budget through 12/19/25

Generate:Biomedicines is seeking an experienced, highly motivated, and innovative Contractor, Associate Scientist, Large-Scale Biotherapeutics Purification to contribute to the development of our drug discovery platform and to drive delivery of our therapeutic pipeline. She/he will be responsible for inventories, aliquoting, performing protein purification and characterization at various scales across a range of different protein modalities, supporting our growing portfolio of projects from mammalian (Transient & Stable) as well as bacterial (E.coli) derived material at both our Somerville, MA and Andover, MA locations.

Responsibilities:

• Freezer inventory management and sample aliquoting
• Perform multi-step protein purifications of various protein modalities (mabs, Fc-fusions, his tags, bi-specifics fabs, etc) leveraging different affinity tags, secondary chromatography, and polishing steps on AKTA systems.
• Assess protein quality metrics for all proteins produced within the team using Agilent systems, HCP/ ProA ELISAs, UV spectrometry, endotoxin assays, SDS-PAGE gels.
• Help explore, assess, and bring in-house state of the art technologies to enhance and continuously improve efficiencies across internal platforms.
• Efficiently accomplish project goals on time and update the team with progress.
• Contribute to non-GMP early-stage R&D purification development from Transient HEK, Transient CHO, Stable CHO and E. coli derived material.
•  Detailed documentation of experiments and data on our internal LIMS systems, electronic notebook and presentations to project teams.

 

Required Skills/Experience:

• MSc/4+ years of related experience or a BSc/6+ years of related experience for an Associate Scientist. Strong candidates will be considered at the Senior Research Associate level with MSc/2-4 years of related experience or a BSc/4-6 years of related experience.  Industry experience strongly preferred.
• Minimum of 1+ years MS/ 3+yrs BS/ of biologics purification experience in a biotech/pharma setting
•  Experience with standard chromatography methods in the Biotherapeutic Discovery and Development setting
• AKTA and Agilent systems or equivalent
• Must be able to run ELISAs, SDS-PAGE, Westerns, and take UV spectrometry measurements
• Buffer Preparation
• Demonstrate sterile aseptic techniques
• Track record of helping to deliver biotherapeutic assets to clinical development
• Proven time management skills
• Excellent communication, attention to detail, documentation, organizational, and technical writing skills

Desired Skills:

• · Preparative Affinity, SEC, IEX, HIC, Mixed Mode chromatography
• · Analytical Affinity, IEX, HIC, Mixed Mode, SEC. RP
• · Familiarity with Inventory databases and ELN

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster.  The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by