Senior Scientist, Immunology, In Vivo Pharmacology

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.    

The Immunology Thematic Research Center at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal innovation engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Furthermore, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise. 

Position Summary

Located at the Cambridge Crossing site in Cambridge, MA, Bristol Myers Squibb is seeking a Senior Scientist, In Vivo Pharmacology, who will be conducting vivo research in the field of autoimmune diseases. This individual will interact seamlessly with other scientists and functional groups within a drug discovery team to formulate and implement the in vivo strategy for the programs in the Immunoscience Portfolio. While the major focus of this position will be the in vivo evaluation of novel therapeutic agents that will support these drug discovery efforts, additional responsibilities include the identification and validation of novel disease and target specific biomarkers, and the development of new pharmacodynamic and disease models for autoimmune indications. Other responsibilities include but are not limited to prepare, review and deliver scientific presentations to internal and external stakeholders; interact with senior management and key opinion leaders.

Key Responsibilities

• Develop therapeutic hypotheses for autoimmune disease(s) based on literature discoveries, in vitro experimental data, in vivo animal modeling, immunological evolution, genetics, clinical data, and technological advances. 
• Collaborate alongside a cross-functional team to discover new targets, derive new biological mechanistic insights, and support in vivo pharmacology needs for programs as they move through clinical development. 
• Identify and implement appropriate PK/PD and disease models to support clinical candidate selection, human dose projection, biomarker identification, and life cycle management.
• Contribute to portfolio strategy discussions and foster external collaborations to advance program objectives.
• Communicate scientific findings effectively across multidisciplinary teams and to leadership.
• Mentor members of the Immunology in vivo Pharmacology team, providing scientific and strategic direction.
• Travel will be less than 5% of the time. 

Qualifications & Experience

• Research experience in the Immunology/Inflammation therapeutic area, with a strong in vivo background.
• Prior hands-on experience with animal models of autoimmune diseases is highly desirable.
• Comprehensive understanding of PK/PD assessments and proven experience designing ex vivo studies for pharmacodynamic and target engagement endpoints.
• A track record of scientific accomplishment.