Senior Program Manager

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

• HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

• HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

• HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

• HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

 

Overview of Role:

The Associate Director of Project Management sits within the Program Management and Business Strategy department and is pivotal in contributing to a fit for purpose PMO and driving cross-functional execution and operational excellence across oncology development programs, particularly Phase 2 and beyond. The Associate Director will serve as a strategic integrator, aligning corporate and clinical development goals with functional execution across departments such as Clinical Operations, Development, Biometrics, Regulatory, Clinical Pharmacology, Biomarker Strategy, Bioanalytical, New Indication Planning, Quality, IT and Compliance.

This role will be responsible for building and refining infrastructure and processes that support scalable, transparent, and adaptive program execution. This includes dashboarding, process improvement and continuous monitoring to ensure visibility, accountability, and agility as the organization grows and our pipeline evolves.

Role and Responsibilities:

• Project Management
  • Develop integrated project plans, timelines, and templates from scratch tailored to program, cross functional, and governance needs.
  • Drive execution of project milestones, proactively identifying risks and mitigation strategies.
  • Ensure alignment between functional execution and strategic program goals.
  • Lead and manage ad-hoc cross functional workstreams on specific initiatives.
• Functional Integration
  • Serve as a project management strategic liaison to 1–2 functional departments (e.g., Clin Ops, Biometrics, Clinical Quality, Clin Dev).
  • Translate functional needs into actionable infrastructure and project plans.
  • Support functional teams in achieving operational excellence and compliance.
• Process Improvement & PMO development
  • Design and implement scalable, adaptable processes that support program execution.
  • Lead initiatives to improve operational efficiency, transparency, and agility.
  • Ensure all infrastructure initiatives are documented and integrated into the PMO library.
  • Apply continuous monitoring and feedback loops to refine processes as the organization evolves.
• Dashboarding & Visibility
  • Develop and maintain dashboards using Smartsheets and other tools to track timelines, deliverables, and risks.
  • Ensure real-time visibility into project status for leadership and stakeholders.
  • Champion data-driven decision-making through effective reporting and visualization.
• Leadership & Collaboration