Senior Scientist, Cancer Immunology Discovery

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients.  Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies.  With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities:

In the role as a Senior Scientist within the Cancer Immunology team, the ideal candidate:

• Synthesizes complex information to propose novel hypotheses and evaluate new target ideas in the Cancer Immunology space

• Uses cutting edge and innovative techniques for identification, validation, and selection of targets to incorporate into multispecific drug candidates

• Executes experiments independently, troubleshoot as needed, interpret, and discuss data at project meetings and department meetings

• Performs laboratory work related but not limited to tissue culture, multi-parametric flow cytometry, western blot, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex/MSD, processing of DNA/RNA/protein

• Maintains accurate and detailed record-keeping

• Presents data at project meetings and department meetings

• Collaborates with rest of biology team members as well as other functional area leads e.g. protein purification, in vivo pharmacology, DMPK, informatics

• Utilizes excellent communication and interpersonal skills

Basic Qualifications :

• Bachelor’s Degree

  • 7+ years of academic and / or industry experience

Or

• Master’s Degree

  • 5+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in Life Sciences

  • 2+ of academic and / or industry experience

Preferred Qualifications:

• PhD with 2-4 years of relevant experience

• Experience and track record in biotherapeutics, immuno-oncology or immunology drug discovery

• Good understanding of vascular, stromal, and immune cell biology (myeloid and T cell biology preferred)

• Experienced in the design, development and optimization of high-throughput cell-based assays to support development of multispecifics

• Proficient with primary human and mouse cell culture, including primary immune cells and cancer cell lines

• Experience with gene expression mo