Senior Scientist - DNA Encoded Library Screen (DEL)

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases.  Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis.  Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

Lead Discovery & Optimization (LDO) is a dynamic organization that supports the entire drug discovery continuum (from lead identification to clinical candidate delivery) at Bristol Myers Squibb. The organization leverages state-of-the-art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, neuroscience and cardiovascular diseases.

We are seeking a highly motivated scientist to design and execute DNA Encoded library Screen (DEL) selections to identify small molecule ligands to support drug discovery programs across the BMS Portfolio. This individual will work independently while being a part of a larger team to drive innovative solutions for next-generation DEL, including the development and improvement of affinity selection techniques. The candidate will collaborate with multidisciplinary science teams, such as therapeutic area representatives, protein sciences, high-throughput screening, and chemistry, to ensure project alignment. The candidate should have the ability to understand diverse target biology and utilize a spectrum of biochemical techniques to prepare DEL libraries for screening, develop protein immobilization and selection methods, and engage in next-generation sequencing. The ideal candidate will have demonstrated experience analyzing large datasets and effectively communicating results to broad project teams. This is a hands-on laboratory-based position.

Duties/Responsibilities:

• Accountable for developing DEL workflows and coordinating the selection efforts to support drug discovery programs across the BMS Portfolio
• Lead efforts to identify, evaluate, and implement new technologies in the DNA encoded library space and push the boundaries to adapt next-gen DEL technologies
• Interact closely with disease biology colleagues, protein science and chemistry to effectively drive cross-functional collaboration on DNA-encoded library selection
• Interface with the Chemoinformatics team to oversee DEL library informatics, NGS and hit analysis.
• Analyze, interpret, and effectively report hit report data at team meetings.
• Work with external partners to effectively drive collaboration

Basic Qualifications   

Bachelor's Degree 7+ years of academic/industry experience

or

Master's Degree 5+ years of academic/industry experience

or

PhD 2+ ye