Manager/Senior Manager CMC Process Chemistry

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

 

Summary:

Tango has an exciting opportunity to join our CMC organization as an innovative, motivated, and scientifically rigorous CMC Process Chemist. Reporting to the Director, Chemical Development, you work closely with internal project team and external CDMOs to seamlessly move development candidate into the IND enabling stage. You will have experience with small molecule process chemistry, route scouting, reaction optimization, and scale-up of chemical processes.

Your Role:

• Interface with medicinal chemistry group in the development of lead molecules; work closely with internal project team and external CDMOs to seamlessly move development candidate into the IND enabling stage.
• Manage phase appropriate API process development and manufacturing at CDMOs from discovery to development; drug substance manufacturing activities including but not limiting to: key building blocks, pre-clinical tox batch deliveries, such as PK/PD lot, DRF/GLP batches etc.
• Process Research and Development: Route scouting, reaction optimization, and scale-up of robust and cost-effective synthetic routes for drug substances by leveraging your deep knowledge of process chemistry.
• Technology Transfer: Ensure smooth transfer of processes from R&D to manufacturing sites or between manufacturing sites.
• Build professional and long-term relationships with contract development and manufacturing organization personnel.
• Collaborate closely with Medicinal Chemistry, Analytical, Formulation, Quality and project teams to ensure seamless flow of information, alignment on project goals and deliver ongoing data as necessary to support continued development progress.
• Resource Allocation: Manage resource allocation and prioritize projects in line with company objectives, ensuring timely and efficient progress.
• Participate in the writing and review of scientific reports and development documents, holding responsibilities for the chemistry sections; document and archive data and reports from CDMOs.
• Employ state-of-the-art tools, techniques, and statistical methodologies to analyze and interpret data, contributing to process understanding and improvement.

 

What You Bring:

• PhD with 3+ years, MS with 6+ years or BS with 10+ years of accomplished experience in small molecule process chemistry in the biotech/biopharma industry.
• Proven experience in route scouting, reaction optimization, and scale-up of chemical processes in a biotech, pharmaceutical, or related industry.
• Excellent problem-solving skills with the ability to approach challenges creatively and pragmatically.
• Demonstrated written and verbal communication skills with ability to work across levels, functions.
• Experience as manager of external teams at CDMOs is a bonus.
• Demonstrate a sense of urgency, proactive thinking, and productivity in a fast-paced entrepreneurial environment.

 

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.