Director, Disease Area Strategy Lead

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Director, Disease Area Strategy Lead

What you will do

Let’s do this. Let’s change the world. As we increase our investment in discovery research and early pipeline development, this role is critical to drive commercial strategy at the earliest stages of innovation. This position requires a leader who understands the intersection of science, strategy, and commercial execution—ensuring that Amgen’s early-stage investments are positioned for long-term success.

The Director, Disease Areas Strategy Lead (DASL) will play a pivotal role in shaping the future of Amgen’s portfolio by providing commercial insights to early-stage research, pipeline programs, and external business development opportunities.

In this role you will be responsible for the following:

• Partnering with Senior Leadership to define Amgen’s early pipeline commercial strategy to ensure investments in research and early development align with long-term business objectives and patient needs.

• Partnering closely with R&D, global marketing, and corporate development teams to assess external innovation and business development opportunities, ensuring alignment with Amgen’s portfolio strategy.

• Supporting portfolio investment decisions for relevant therapeutic areas in coordination with the Enterprise Portfolio Governance function.

• Developing commercial frameworks and business cases to inform progression decisions for early-stage assets, integrating insights from market dynamics, patient needs, and competitive intelligence.

• Building a best-in-class commercial function for early pipeline strategy, ensuring Amgen maintains a leadership position in bringing first-in-class and best-in-class therapies to market.

Key activities and accountabilities include the following:

Early Pipeline Strategy & Portfolio Prioritization

• Create and leverage frameworks for evaluating and prioritizing early-stage assets across Amgen’s portfolio.

• Support the assessment of commercial viability and differentiation of assets in early development, ensuring alignment with evolving market needs and payer landscapes.

• Partner to shape long-term portfolio strategy in collaboration with R&D, finance, and business development teams.

• Preparation of business cases along with other execution-based deliverables to business needs

Commercial Partnership with Research & Early Development

• Provide commercial input to research-stage investment decisions, ensuring a clear path to differentiated and commercially viable products.

• Collaborate with R&D to develop target product profiles (TPPs) that reflect strong commercial positioning.

• Establish strong cross-functional partnerships with R&D, corporate strategy, finance, and global marketing teams

Business Development & External Innovation

• Partner with Amgen’s Business Development team to evaluate in-licensing, partnerships, and acquisitions for early-stage assets.

• Support the commercial due diligence process on external opportunities, integrating scientific innovation with market insights.

Enterprise Portfolio Governance & Investment Strategy

• Play a role in the Portfolio Governance process, ensuring that commercial insights drive R&D investment decisions.

• Align early-stage investments with Amgen’s strategic growth objectives and therapeutic area priorities.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a strategic leader with these