Director of Translational Medicine - Immunology

Who we are

Together, we’re on a mission to make good health more affordable and accessible, to help millions around the world enjoy healthier lives. It’s a mission that bonds our people across nearly 60 countries and a rich, diverse variety of nationalities and backgrounds. Working here means working with the world’s leading manufacturer of generic medicines, and the proud producer of many of the products on the World Health Organization’s Essential Medicines List. Today, at least 200 million people around the world take one of our medicines every single day. An amazing number, but we’re always looking for new ways to continue making a difference, and new people to make a difference with.

The opportunity

The Translational & Precision Medicine Leader (TPML) will be accountable for designing and implementing TPM strategies for assigned drug assets. The TPML will lead a cross-functional TPM Project Team(s) in a matrix environment and will be responsible for the planning, design, execution, and data interpretation of translational and precision medicine studies, across all phases of drug development, in accordance with Teva strategy and priorities, including timely composition of study reports and other relevant documentation. In addition, the TPML will lead biomarker discovery and development research initiatives associating molecular, histologic, radiographic, physiologic and digital biomarkers with drug response, safety and/or compliance. This role will work in close collaboration with various discovery, preclinical and clinical development functions to identify opportunities for enhancing the selection of new candidates and will lead the deployment of comprehensive TPM scientific plans for the selected candidates to move quickly into clinical development, including further development of these plans throughout the life cycle of the compound. The TPML will represent Teva externally as needed and will interact and foster relationships with KOLs, external academic collaborators, regulatory inspectors and auditors in the assigned therapeutic area.

Travel Requirements:  Approximately 10-15% - presentations and/or attendance at approximately 2 domestic and/or 1 domestic + 1 international scientific association meeting per year, plus key opinion leaders, scientific advisory boards regulatory meetings, academic collaborations, consortia and other strategic meetings as required.

How you’ll spend your day

Essential Duties & Responsibilities:

• Independently and innovatively devises strategic TPM strategy for de-risking all programs within the assigned therapeutic area (TA).
• Prepares and manages TPM Plans to enhance probability of success of assigned clinical programs in collaboration with relevant functions. 
• Leads a cross-functional TPM Project Team(s) in a matrix environment.
• Leads the selection, planning, design, execution, and data interpretation of TPM studies with scientific rigor and innovative approaches.
• Leads biomarker discovery and development research initiatives associating molecular, histologic, radiographic, physiologic or digital biomarkers with drug response, safety and/or compliance.
• Advises TA and other relevant R&D functions as an expert in all TPM related aspects of science, medicine, regulatory strategy, intellectual property (IP), assay development, commercial value, etc. Provides expert support to the evaluation of in-licensing compound and collaboration opportunities as needed.
• Works in collaboration with TA leadership to enhance a candidate selection and to develop comprehensive TPM scientific (de-risking) plans for each of the prioritized candidates selected to move into the clinic. Further develops these plans throughout the life cycle of the compound.
• Designs programmatic translational strategies and study-specific biomarker studies, composing the relevant documentation and being accountable for its on-time execution.
• Works with outside departments to ensure collaboration and selection of cost-effective and appropriately validated assays, delivered on time in relevant programs.
• Assesses providers and ensures the availability and subscription to tools and databases that enable rapid access to relevant in silico data from a wide variety of external sources for internal decision making, to inform biomarker strategies and facilitates interpretation of results.
• Aligns with Biostatistics on statistical analysis plan (SAP) templates, tools and data analytical approaches and ensures co-development of the SAP, or equivalent, of TPM programs within and parallel to the clinical program for all relevant programs at Teva.
• Evaluates data sets from Biostatistics, employs tools and literature review to interpret the biological relevance, and presents final assessments to clinical and core teams along with specific recommendations related to T