Research Scientist II/Senior Scientist I, Biologics Engineering & Assays

Job Description Summary

Position is on-site in San Diego, CA.
#LI-Onsite

About the role:
The Novartis Biologics Research Center (BRC) is seeking a highly motivated Research Scientist II/Senior Scientist I with the skills and experience to contribute to advancing biotherapeutic drugs to patients in need. This is a great opportunity to join a group dedicated to protein, antibody, and antibody-drug-conjugate discovery. In this role, you will be a member of several multidisciplinary teams in a variety of disease areas, you will support the Novartis portfolio and be a key player in advancing drug discovery projects.

 

Job Description

Your Key Responsibilities:

Your responsibilities include, but are not limited to:

• Design and make different types of biologics (antibodies, conjugates, bispecific antibodies etc) using molecular biology tools.
• Coordinate or execute expression and purification of biologics and be accountable for interpreting analytical results to maintain quality of outputs.
• Conduct functional assays, including generating and maintaining stable cell lines.
• Contribute to analysis and synthesis of results, design of new experiments and clear communication of scientific progress to project team(s); troubleshoot experiments and suggest mitigation strategies.
• Work effectively as a member of cross-functional teams to accomplish shared project goals.
• Contemporaneous and accurate documentation in sample databases and electronic notebooks

Role Requirements:

• BS or MS degree in biology, biochemistry, molecular biology, or related discipline with at least 2+ years of relevant academic or industry laboratory experience
• Experience with mammalian cell culture and a solid understanding of best practices for aseptic technique.
• Excellent technical ability, attention to detail, and an eagerness to learn new things.
• Proficiency in designing and conducting experiments, and to analyze, interpret and communicate data.
• Knowledge of molecular biology techniques for the design and generation of plasmid constructs for protein expression and use of standard DNA software (eg Lasergene, Snapgene, Vector NTI)
• Experience with standard protein biochemistry techniques such as SDS-PAGE, antibody and protein purification, and familiarity with interpretation of biophysical measurements.

This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered (Research Scientist II/Senior Scientist I):

• Research Scientist II: 2+ years of relevant academic or industry laboratory experience
• Senior Scientist I: 5+ years of relevant academic or industry laboratory experience

Desired Requirements:

• Experience with any of the following:
• Characterizing antibodies based on binding, specificity, or functional activities.
• Cell line generation and cell-based assays
• Protein and antibody labeling/conjugation
• Familiarity with flow cytometry, ELISA, or SPR binding measurements
• Analysis of experiments in related software such as Excel (including basic macro programming), Prism, Spotfire, FlowJo, Octet, etc.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining

to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through co