Sr. Scientist Immunology Discovery

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

About Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

 

We are searching for the best talent for a Senior Scientist to be in San Diego, CA.

The successful individual will provide bench support for discovery projects testing novel interventions/compounds in complex in vivo models of inflammation and in vitro systems, generating preclinical pharmacology, biomarker, and human translational data to support regulatory filings for new molecular entities, and collaborate with cutting edge academic labs and biotech companies. This individual will also participate in efforts to identify new targets for therapeutic intervention for inflammatory indications impacting skin, gut, joint, and lung.

Key Responsibilities:

• Design, perform, and interpret in vitro experiments to support target validation, mechanism of action studies, and progression of drug discovery programs.
  • Design and conduct in vivo and ex vivo pharmacology experiments with a high degree of autonomy to understand drug exposure/activity relationship.
  • Develop, troubleshoot, and validate new in vivo models (acute or chronic) and lead/instruct other team members regarding processes, techniques, or tasks.
  • Employ in silico approaches to interrogate multi-omic datasets to identify key molecular features and cellular mechanisms and pathways contributing to disease pathogenesis in tissues of interest (e.g. skin, gut, joint, lung).  
• Document research in internal discovery reports, manuscripts for external publication, and other formats as required.
• Present research at internal meetings and external scientific forums.
• Work closely with colleagues from partner organizations to enable and/or support research activities.
• Work with leadership to establish and maintain involvement in any external collaborations required to support research goals.

Requirements:

• PhD in Immunology/Pharmacology/Cell Biology or related discipline with 1-3 years additional lab experience.
• Experience with in vitro cell culture (e.g. adherent cells and immune cells) is required.
• Experience with in vivo techniques (e.g.. rodent handling, IP/SC/PO dosing, tissue harvesting, inflammatory models) is required.
• Experience with standard methods for assessment of