Senior Associate Scientist, Protein Solutions– Binding Kinetics

Role Summary:

We are seeking a motivated and enthusiastic individual who will be performing binding kinetics using biolayer interferometry (BLI) and surface plasmon resonance (SPR) to support the binding kinetics needs of the Oncology Research Unit at Pfizer. The primary objective of this position is to aid in the characterization of our proteins and small molecules for multiple programs. This position will provide an excellent opportunity to gain hands on experience in contributing to the drug development process in an industry setting. 

Role Responsibilities:

• Design and perform protein binding kinetic experiments using BLI and SPR.
• Analytical characterization of proteins via analytical SEC, mass spectrometry, SDS-PAGE, UV-Vis, intrinsic fluorescence, or related techniques.
• Biotinylation of recombinant proteins.
• Process proteins including buffer exchange, protein concentration adjustment, aliquoting, and storage.
• Manage and track binding requests and samples.
• Data analysis, report generation, and presentation of results.
• Document all work in an electronic laboratory notebook. 
• Balance workload and changing priorities to efficiently contribute to kinetic research collaborations.

Basic Qualifications:

• Bachelor’s degree in Biological Sciences or related discipline with 3+ years lab experience in an academic and/or industry environment.
• Experience with performing plate-based assays or protein binding assays such as binding kinetics (Biacore/Octet), ELISA, or Flow Cytometry.
• Strong understanding of experimental design and familiarity/experience with basic biochemical principles and techniques.
• Strong attention to detail while following protocols and with data representation.
• Commitment to high quality analysis and documentation with the ability to organize, analyze and interpret, and effectively communicate individual results. 
• Ability to perform routine tasks independently, more advanced tasks under direction and complete work as part of a team.

Preferred Qualifications:

• 1-3 years of experience with performing and designing kinetic binding assays on Octet, Biacore, Carterra, or other related protein kinetics instruments.
• Strong understanding of sensorgram analysis theories.
• Tracking inventory and/or requests through computer systems, Smartsheet, or Excel.
• Basic knowledge of antibody biochemistry, understanding of immunological functions and systems.
• Experience with labeling proteins with a small molecule like biotin.

Additional Information:

• Work Location: On Premise
• Last Day to Apply: September 14, 2024

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the S