Senior Site Activation Manager (SAM) Sponsor-Dedicated (FSP) | Remote – Americas Based

Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.
 
Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
 
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
 
Discover what your 25,000 future colleagues already know:
 
Why Syneos Health
• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose ��� Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life. 
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress. 

Job Responsibilities

Senior Site Activation Manager (SAM)

Sponsor-Dedicated (FSP) | Remote – Americas Based

 

Why This Role

This is a high-visibility opportunity for outstanding Site Activation Managers ready to step into a more strategic, sponsor-facing role within an FSP model. You’ll lead global site activation efforts while helping shape processes in a fast-evolving environment.

What You’ll Own

End-to-End SSU Leadership

• Drive global site start-up strategy and execution from site identification through activation and lifecycle maintenance

• Own SSU timelines, forecasts, and delivery against contracted milestones

• Identify risks early (regulatory, enrollment, timelines) and implement mitigation plans

Operational Oversight

• Lead all start-up deliverables, including:

  • Site identification and feasibility

  • Regulatory submissions and lifecycle maintenance (amendments, HA/EC communications, licenses)

  • CTA and investigator budget negotiation/execution

  • Essential document collection and TMF readiness

• Ensure delivery aligns with SOPs, sponsor expectations, and quality standards

Sponsor & Cross-Functional Engagement

• Act as a key interface with sponsor stakeholders, presenting strategy, risks, and status

• Partner across Clinical Ops, PM, Contracts, Data Management, Medical Writing, and SSU Country teams

• Collaborate within a team-first, highly accountable FSP environment

Financial & Scope Accountability

• Review SSU budgets vs. milestones and support profitability targets

• Track and manage out-of-scope activities in partnership with PM/SSU leadership

Regulatory Leadership

• Oversee preparation of core submission documents and amendment dossiers

• Conduct Regulatory Impact Assessments and communicate risks

• Support development of SIS/ICF documents and country-specific submissions

Process & Build Mindset

• Contribute to process creation and refinement as the team scales

• Operate effectively in a setting where execution and process development happen in parallel

Required Experience

• Minimum 3 years prior experience as a Site Activation Manager (SAM).

• Minimum of 2 years' experience in Managing large scale, US-based Site Activation with high success.