Associate Scientific Director, Analytical Development

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

About the Role:

This position will serve as a subject matter expert and analytical liaison for research and early-stage development projects, with a focus on mass spectrometry characterization of antibodies, conjugates, and other large molecules. Evaluate the developability of development candidates by performing structure elucidation, chemical stability assessments, and forced degradation studies. Accumulate product and process understanding to guide lead-optimization, process development, and formulation development. Serve as Analytical Development Lead and support and oversee all the analytical activities related to drug substance and drug product development from preclinical through commercial phases, including method development, validation/qualification, specification establishment, and control strategy development. Contribute to biomarker discovery via proteomics analysis and targeted quantification across modalities and functional areas. Responsible for keeping work in compliance with GxP, safety, and regulatory requirements. Contribute to analysis and evaluation of material and products at all stages of development process. Supervise junior scientists through coaching and evaluating completion of tasks and projects.

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Your Contributions (include, but are not limited to):

• Establish collaborative and productive working relationships with key partner organizations to build cross-project analytical alignment and consistent developability criteria through a matrix, cross-functional analytical characterization strategy aligned with broader business objectives
• Define discovery-stage critical quality attributes (CQAs) aligned with target product profiles (TPPs) to guide molecule engineering and optimization, support risk-based developability assessment, and establish early product and process understanding
• Evaluate development candidate developability by performing structure elucidation, chemical stability and forced degradation studies. Collect developability and characterization data to guide lead-optimization within Research, process and formulation development within Technical Operations
• Serve an Analytical Lead in leading analytical development activities for the characterization of antibod